文章摘要
史宝林,张勇,武艳华,张杰.脑梗死的遗传流行病学研究[J].中华流行病学杂志,2003,24(8):719-721
脑梗死的遗传流行病学研究
A study on genetic epidemiology of cerebral infarction
收稿日期:2002-10-13  出版日期:2014-09-16
DOI:
中文关键词: 脑梗死;遗传流行病学
英文关键词: Cerebr al infarction;Genetic epidemiology
基金项目:
作者单位
史宝林 张家口医学院预防医学教研室 075029 
张勇 河北医科大学 
武艳华 张家口医学院预防医学教研室 075029 
张杰 张家口医学院预防医学教研室 075029 
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中文摘要:
      目的 探讨脑梗死的遗传方式以及遗传因素在脑梗死发病中的作用。方法 采用遗传流行病学配对病例对照研究方法,对 112对脑梗死先证者家系和对照家系的脑梗死发病情况进行研究,使用Li Mantel Gart法及Falconer法估算脑梗死的分离比和遗传度。结果 病例组一、二级亲属脑梗死患病率明显高于对照组亲属 (P <0.05 ) ;分离比为 0.1437(0.1130~ 0.1744 ),显著低于0.25,不符合单基因遗传性疾病的特征 ;遗传度估算结果,患者一、二级亲属遗传度分别为 47.84 %±4.55 %和 40.95 %± 13.05 %,其中男性高于女性。结论 脑梗死属多基因遗传方式,遗传因素对其发病有一定的作用。
英文摘要:
      Objective To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.Methods A matched case-control study including 112 pairs pedigrees was carried out. Using the L-i M ante-l Gart method and the Falconer method to estimate the segreg at ionratio and the heritability of cerebral infarction.Results The prevalence rate of the firs-t degree and the second-degree relatives in cases was significantly higher than that in controls.The seg regation ratio was 0.1437 (0.1130- 0.1744),significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the firs-t degree and the second-degree relatives were 47.84% and 40.95% higher in males than in females. Conclusion Cerebral infarction was a poly genetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males
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