| 邱昌建,唐牟尼,张伟,韩海英,戴静,卢江,吴赛,王双红,陈建民,郭林晋,丁玉琼,李胜先,刘协和.成都地区55岁及以上人群轻微认知功能损害患病率调查[J].中华流行病学杂志,2003,24(12):1104-1106 |
| 成都地区55岁及以上人群轻微认知功能损害患病率调查 |
| The prevalence of mild cognit ive impairment among residents aged 55 or over in Chengdu area |
| 收稿日期:2002-03-05 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 阿尔茨海默病 轻微认知功能损害 患病率 |
| 英文关键词: Alzheimer' s disease Mild cognitive impairment Prevalence |
| 基金项目:纽约中华医学基金会资助项目(99699) |
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| 中文摘要: |
| 目的 调查成都地区 5 5岁及以上人群轻微认知功能损害 (MCI)的患病率。方法 采用分层随机整群抽样方法从成都市所辖 19个区、县 (市 )抽取样本,调查分为筛查、复查诊断两个阶段。筛查用一般情况量表、简易精神状态检查表 (CMMSE)、抑郁自评量表 (CES D)、体格检查及神经系统检查表,复查诊断用老年期痴呆诊断问卷、临床痴呆评定量表 (CDR)。MCI诊断标准参照Petersen等诊断标准 :①主诉记忆损害 ;②日常生活能力正常 ;③一般认知功能正常 ;④与年龄不符的记忆损害,认知检查有记忆损害 ;⑤达不到痴呆标准 ;⑥CDR评分 0.5 ;⑦排除抑郁等原因引起的可逆性认知损害。结果 实查 3910人,MCI的患病率为 2.4 %。城镇MCI的患病率为1.5 %,农村为2.5 %,两者差异无显著性。男性MCI患病率为 1.8%,女性为2.9%,女性高于男性,差异有显著性(χ2 =5.6 34,P =0.0 18)。文盲MCI患病率 4.0 %,明显高于非文盲者。随年龄增长MCI累积患病率增加,且女性高于男性。结论 MCI患病率 (2.4 % )较成都同一地区阿尔茨海默病 (AD)的患病率(2.05 % )略高。MCI患者是AD高危群体,需进一步随访及采取早期干预措施。 |
| 英文摘要: |
| Objective To study the prevalence of mild cognitive impairment (MCI) in the urban and the rural areas in Chengdu, Southwest China.Methods Residents aged 55 o r over w ere selected by stratified random cluster sampling from 19 districts, cities, and counties of Chengdu area in Sichuanprovince.A two-stage survey was carried out.In the first stage, CMMSE, CES-D were used as screening instruments.In the seco nd stag e, Diag nostic questionnaires o f dementia and CDR were used as diagnostic instruments.The diag nostic criteria of mild cognitive impairment adopted from Petersen' s were :(1)memory complaint ;(2) normal activities of daily living ;(3) no rmal general cognitive function ;(4)memory impairment incompatible with age ;(5)not demented ;(6)CDR =0.5 and (7)exclusion of thereversible cognitive impairment caused by other factor s (i.e.depression).Results Three thousand, nine hundren and ten subjects were ex amined.The prev alence rates of MCI was 2.4%.The MCI prevalence rates in the urban and the rural areas w ere 1.5 %, 2.5 % respectively, without significant difference.The MCI prevalence in males and females w ere 1.8%, 2.9 % respectively.Prevalence rate in female was higher than in males with significant difference.Prevalence of illiteracy (4.0 %)w as the hig hest among different educatio nal lev els.The accumulated prevalence increased with age.Conclusion The prevalence of MCI (2.4 %)w as slig htly hig her than the prevalence of AD (2.05 %) in the same areas of Chengdu.MCI seemed to be a hig h risk factor for AD which should to be followed up.Early intervention in MCI might be helpful in the prevention of AD. |
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