文章摘要
成金罗,沈默宇,周玲,王劲松.125个家族高发性2型糖尿病的危险因素研究[J].中华流行病学杂志,2004,25(2):162-164
125个家族高发性2型糖尿病的危险因素研究
A study on risk factors among 125 type 2 diabetes mellitus with familial tendency
收稿日期:2003-04-24  出版日期:2014-09-15
DOI:
中文关键词: 糖尿病,2型  危险因素  遗传度
英文关键词: Diabetes mellitus,type 2  Risk factors  Heritability
基金项目:江苏省社会发展基金(BS200031)
作者单位
成金罗 南京医科大学附属常州第二医院内分泌科, 常州 213003 
沈默宇 南京医科大学附属常州第二医院内分泌科, 常州 213003 
周玲 南京医科大学流行病与卫生统计学系 
王劲松 南京医科大学流行病与卫生统计学系 
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中文摘要:
      目的 研究家族高发性2型糖尿病家系人群中可能的遗传和环境危险因素。方法 对1999~2001年门诊及住院的125个家庭高发性2型糖尿病先证者的家庭成员调查家族信息和环境危险因素,比较2型糖尿病患者、糖耐量减低(IGT)患者与非患者在环境危险因素的差异。采用Falconer法估算遗传度,用Penrose法进行多基因分析研究其遗传危险性。结果 三组人群甘油三酯、体重指数、腰臀比值、高血压史及体力活动史的构成比差异有极显著性(P<0.01),而其他血脂项目及冠心病史差异未见显著性。125个大家系的2型糖尿病遗传度为83.42%±5.84%,提示在这些家系中可能有显性主基因存在。多基因分析研究表明在该人群中,2型糖尿病可能符合多基因遗传模式。结论 2型糖尿病为多基因疾病,环境危险因素和遗传因素及其交互作用可能影响其发病。
英文摘要:
      Objective To study the risk factors regarding heredity and environment in familial incident type 2 diabetes mellitus (DM). Methods To compare the difference of environmental risk factors between type 2 DM, impaired glucose tolerance (IGT) and normal persons through study on familial information and environmental risk factors in 125 familial incident type 2 DM in-patients and out-patients from 1999 to 2001. Falconer was used to estimate heritability. Penrose was used to study the heredity damagers by polygene analysis. Results There was a significant constiuent ratio diversity (P 0. 01) in triglyceride, body mass index, waist to hip ratio, hypertension history and physical activities history among 3 groups, while no significant diversity in blood lipids and history of coronary heart disease. 83. 42%± 5. 84% heritability of type 2 DM in 125 familial predigree indicated that dominant major gene might exist in these familiar pedigrees. Analysis of polygene in these groups showed type 2 DM might conform to the model of polygene heredity. Conclusion This study suggested that type 2 DM had significant heritability and genetic heterogeneity, which generally appeared to be a disease of multi--factorial inheritance. Environmental risk factors, genetic factors and their interactions were due to type 2 DM.
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