文章摘要
龚震宇,翁景清,赵芝雅,陈毓土,祝阿根,傅桂明,方春福,朱智勇,陈恩富,汪垂章,王玮,雷林海,王臻.肾综合征出血热疫苗免疫后血清学监测[J].中华流行病学杂志,2004,25(5):400-402
肾综合征出血热疫苗免疫后血清学监测
Serological surveillance on hemorrhagic fever renal syndrome after vaccination
投稿时间:2003-03-28  
DOI:
中文关键词: 肾综合征出血热;灭活疫苗;血清学;监测
英文关键词: Hemorrhagic fever renal syndrome;Inactivated vaccine;Serology;Surveillace
基金项目:国家“九五”医学科技攻关课题资助项目(96-906-13)
作者单位
龚震宇 浙江省疾病预防控制中心, 杭州 310009 
翁景清 浙江省疾病预防控制中心, 杭州 310009 
赵芝雅 浙江省疾病预防控制中心, 杭州 310009 
陈毓土 龙游县疾病预防控制中心 
祝阿根 龙游县疾病预防控制中心 
傅桂明 浙江省疾病预防控制中心, 杭州 310009 
方春福 衢州市疾病预防控制中心 
朱智勇 浙江省疾病预防控制中心, 杭州 310009 
陈恩富 浙江省疾病预防控制中心, 杭州 310009 
汪垂章 衢州市疾病预防控制中心 
王玮 衢州市疾病预防控制中心 
雷林海 龙游县疾病预防控制中心 
王臻 浙江省疾病预防控制中心, 杭州 310009 
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中文摘要:
      目的: 监测肾综合征出血热(HFRS)疫苗免疫接种人群血清抗体水平变化并评价疫苗血清学效果。方法: 以村为单位, 16~60岁健康者(删除既往患HFRS者、外出9个月及疫苗禁忌症者)为观察对象, 按接种和对照各半的原则随机分组, 接种组共10460人, 对照组16159人。采用间接免疫荧光法测特异性IgG荧光抗体, 用微量细胞病变中和试验测中和抗体。结果: 接种前血清抗体阴性者全程接种后2周荧光抗体阳转率为100.0% (67/67, 95% CI: 96.3~100.0), 中和抗体阳转率为44.4% (8/18, 95%CI:22.0~69.0), 几何平均滴度分别为72.1和4.6。1年后进行加强免疫, 加强免疫前、免疫后2周, 免疫后1年、1.5年、2年、3年和5年, 荧光抗体阳性率分别为28.6%、83.3%、75.0%、53.1%、22.6%、10.0%、55.0%; 中和抗体阳性率分别为14.8%、55.6%、35.0%、31.3%、26.0%、10.0%、50.0%。免疫(感染)增强反应需要进一步研究。结论: HFRS疫苗免疫效果良好,血清抗体持续时间较长。
英文摘要:
      Objective: To observe the serological and epidemiological efficacy of hemorrhagic fever renal syndrome(HFRS) vaccine in Zhejiang province. Methods: Immunofluorecent antibody assay and Mcro-CPE method were used to test specific IgG antibody and the titer of neutralizing antibody. Results: Two weeks after the injection of the third dose, the sero-conversion rates by both immunofluorecent antibody test(IgG) and neutralization test were 100.0% (67/67) (95% CI:96.3-100.0) and 44.4%(8/18) (95% CI 22.0-69.0) with geometric mean titers(GMTs) 72.1 and 4.6 respectively. The rates of seroconversion of immunofluorescent antibody by immunofluorescence antibody assay(IFA) were 28.6%, 83.3%, 75.0%, 53.1%, 22.6%, 10.0% and 55.0% before reinforcement, two weeks, one year, one year and a half years, two years, three years and five years after reinforcenment. The rates of neutralizing antibody seroconvversion by the Mcro-CPE method were found as 14.8%, 55.6%, 35.0%, 31.3%, 26.0%, 10.0% and 50.0% respectively. We found some antibody dependent immunization enhancement phenomenon among the inoculated population, but futher observation was needed. Conclusion: HFRS vaccine was immunologically effective and the duration of serous antibody last long.
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