文章摘要
穆丽娜,丁保国,陈传炜,卫国荣,周学富,王如鸿,蔡琳,张作风,姜庆五,俞顺章.亚甲基四氢叶酸还原酶677基因多态性与胃癌危险度关系病例对照研究[J].中华流行病学杂志,2004,25(6):495-498
亚甲基四氢叶酸还原酶677基因多态性与胃癌危险度关系病例对照研究
A case-control study on the relationship between methyl-tetra-hydrofolic acid reductase 677 gene polymorphism and the risk of stomach cancer
收稿日期:2003-05-08  出版日期:2014-09-17
DOI:
中文关键词: 胃肿瘤;亚甲基四氢叶酸还原酶;基因多态性;病例对照研究
英文关键词: Stomach neoplasms;Methyl-tetra-hydrofolic acid reductase;Genetic polymorphism;Case-control study
基金项目:
作者单位
穆丽娜 复旦大学公共卫生学院 上海200032 
丁保国 江苏省泰兴市疾病预防控制中心 
陈传炜 复旦大学公共卫生学院 上海200032 
卫国荣 复旦大学公共卫生学院 上海200032 
周学富 江苏省泰兴市疾病预防控制中心 
王如鸿 江苏省泰兴市疾病预防控制中心 
蔡琳 福建医科大学 
张作风 University of Califomia, Los Angles School of Public Health 
姜庆五 复旦大学公共卫生学院 上海200032 
俞顺章 复旦大学公共卫生学院 上海200032 
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中文摘要:
      目的 探讨亚甲基四氢叶酸还原酶(MTHFR)677基因多态性与胃癌危险度的关系。方法 采用以人群为基础的病例对照研究方法,聚合酶链反应-限制性片段长度多态性法用于检测MTHFR677的基因型。结果 胃癌病例组中,MTHFR677 C/C、C/T、T/T三种基因型的频率分别为25.8%、54.6%、19.6%。对照组中三种基因型频率分别为34.5%、50.9%、14.6%。以C/C基因型作为参照基因型,C/T或T/T两种基因型的OR值为1.52(95%CI:1.04~2.23)。胃癌病例组中C和T两种等位基因型频率分别为53.3%和46.7%,对照组中分别为60.0%和40.0%。以C等位基因为参照,T等位基因的OR为1.31(95%CI:1.02~1.69)。此外研究还显示:MTHFR677AnyT基因型可能与吸烟、霉变粮食、大麦粥摄入、盐的过量摄入以及幽门螺杆菌CagA的感染发生交互作用而增加个体患胃癌的危险度。而该基因型与饮酒和饮茶未见明显的交互作用。结论 当个体携带C/T或T/T基因型时,患胃癌的危险度上升;携带AnyT基因型还可与其他环境危险因素发生交互作用,增加个体患胃癌的危险度。
英文摘要:
      Objective To explore the relationship between methyl-tetra-hydroflic acid (MTHFR) 677 gene polymorphism and the risk of stomach cancer.Methods A population based case-control study was conducted and polymerase chain reaction-restriction fragment length poymorphism (PCR-RFLP) method was used to detect its genotypes.Results Among cases with stomach cancer,the frequency of C/C, C/T, T/T genotype were 25.8%,54.6%,19.6%,compared with controls as 34.5%,50.9%,14.6% respectively.Using C/C genotype as reference,the OR of C/T or T/T genotype was 1.52(95% CI: 1.04-2.23).53.3% C and 46.7% T allele were distributed in stomach cancer cases,while 60.0% C and 40.0% T in controls.The OR for T allele in relation to C allele was 1.31 (1.02-1.69) when C allele was used as reference.In addition,the present study showed that MTHFR677 AnyT genotype might interact with smoking,moldy food intake,wheat porridge intake, eating salty food and Hp CagA infection to increase the risk of stomach cancer.No interaction was observed between MTHFR677 AnyT genotype and alcohol drinking or green tea intake.Conclusion MTHFR77 AnyT genotype,might increase the risk of stomach cancer development and the genotype might also interact with other environmental risk factors to increase the risk of stomach cancer.
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