| AlinaV.Brenner,王作元,Ruth A.Klcinerman,王陇德,Catherine Metayer,Jay H.Lubin.月经和生育因素对妇女肺癌危险度的影响[J].中华流行病学杂志,2004,25(7):590-593 |
| 月经和生育因素对妇女肺癌危险度的影响 |
| Influence of menstrual and reproductive factors on the risk of lung cancer |
| 收稿日期:2003-07-03 出版日期:2014-09-17 |
| DOI： |
| 中文关键词: 肺肿瘤 生育史 月经 女性 危险因子 |
| 英文关键词: Lung neoplasms Reproductive history Menstruation Female Risk factors |
| 基金项目: |
| 作者 | 单位 | | AlinaV.Brenner | Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,USA | | 王作元 | 中国疾病预防控制中心辐射防护与核安全医学所 | | Ruth A.Klcinerman | Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,USA | | 王陇德 | 中国卫生部 | | Catherine Metayer | Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,USA | | Jay H.Lubin | Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,USA |
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| 中文摘要: |
| 目的 验证雌激素可能对肺癌危险度产生的影响 方法 1994～1998年在甘肃省陇东地区进行了-项女性人群的病例对照研究，分析了月经和生育因素与肺癌危险度之间的关系.病例组为109例女性肺癌病例和435名女性为对照组，对照组是根据人口调查资料，按年龄和地区与病例频数匹配得到的.结果 初潮年龄晚(趋势检验P=0.015)、绝经年龄晚(趋势检验P=0.074)的女性，其肺癌比值比较低.结论 尽管有局限性，上述发现表明雌激素在女性肺癌病因学中起到-定作用. |
| 英文摘要: |
| Objective Hypothesis showed that women have higher risks of lung cancer than men when given similar levels of tobacco exposure,implying that sex-related hormones might have a role to play.The study is to identify the influence of female horm ones on risk of lung cancer.Methods We evaluated the association between lung cancer risk and menstrual/reproductive factors on a subset of self-responding females in a population based case-control study in Eastern Gansu.1994-1998.The analysis included 109 lung cancer cases and 435 controls selected from the census list and matched to cases on age and prefecture.Results Odds ratios were lower for later ages at menarche(trend,P=0.0 1 5)and later ages at menopause(trend,P=0.074).Conclusion Despite limitations,these findings suggested a possible role related to horm ones in the etiology of lung cancer in females. |
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