X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性

朱虔兮; 边建超; 沈强; 江峰; 汤洪伟; 张宏伟; 吴毅

文章摘要

朱虔兮,边建超,沈强,江峰,汤洪伟,张宏伟,吴毅.X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性[J].中华流行病学杂志,2004,25(8):702-705

X线交错互补修复基因1多态与乳头状甲状腺癌的遗传易感性

Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma

收稿日期:2003-07-03 出版日期:2014-10-08

DOI：

中文关键词: 乳头状甲状腺肿瘤 X线交错互补修复基因1 基因多态遗传易感性危险因素

英文关键词: Papillary thyroid carcinoma X-ray repair cross-complementing gene 1 Genetic polymorphism Genetic

基金项目:

作者	单位	E-mail
朱虔兮	复旦大学公共卫生学院流行病学教研室
边建超	复旦大学公共卫生学院流行病学教研室	jcbian@shmu.edu.cn
沈强	复旦大学公共卫生学院流行病学教研室
江峰	复旦大学公共卫生学院流行病学教研室
汤洪伟	复旦大学附属肿瘤医院头颈肿瘤科
张宏伟	复旦大学附属肿瘤医院头颈肿瘤科
吴毅	复旦大学附属中山医院普外科

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中文摘要:

目的探讨X线交错互补修复基因1(XRCC1)多态与乳头状甲状腺癌(PTC)的关系.方法采用以医院为基础的配对病例对照研究设计,应用聚合酶链反应-限制性片段长度多态性技术检测105对病例和对照的XRCC1基因多态.结果病例组和对照组XRCC1第194密码子的Arg/Arg、Arg/Trp和Trp/ Trp基因型频率分别为47.6%、49.5%、2.9%和45.7%、48.6%、5.7%,两组差异无显著性(Y²=1.07,P=0.59).病例组和对照组第399密码子的Arg/Arg、Arg/Gin和Gln/Gln基因型频率分别为46.7%、41.9%、11.4%和54.2%、42.9%、2.9%,两组差异有显著性(X²=6.40,P= 0.04).以Arg/Arg基因型为参照,Gln/Gln基因型者发生PTC的风险增加,OR值为4.65(95%CI:1.24～17.45).多因素条件logistic回归分析表明,第399密码子基因多态和负性生活事件与PTC存在正关联,OR值分别为2.71(95%CI:1.22～6.05)和5.34(95%CI:1.40～20.38);X线照射史与PTC存在负关联,OR值为0.38(95%CI:0.12～0.72);未发现第194密码子基因多态、饮茶、水果和经济水平与PTC存在关联.结论XRCC1第399密码子Gln/Gln基因型可能是PTC的易感基因型,负性生活事件是PTC的可能危险因素,X线照射史是PTC的可能保护因素.

英文摘要:

Objective To study the association of polymorphisms in the X-ray repair cross-complementing gene 1 (XRCC1) and papillary thyroid carcinoma (PTC).Methods A hospital based,matched case-control study was carried out. The polymorphisms in XRCC1 for 105 pairs of cases with PTC and controls were identified by PCR-RFLP.Results The frequencies of Arg/Arg,Arg/Trp and Trp/Trp genotypes at XRC-C1 Arg194Trp site were 47.6%,49.5% and 2.9% among cases compared to 45.7%,48.6% and 5.7% among controls.There was no statistically sig-nificant difference between the two groups (χ²=1.07,P=0.59).The frequencies of Arg/Arg,Arg/Gln and Gln/Gln genotypes at XRCC1 Arg399Gln site were 46.7%,41.9% and 11.4% among cases,while 54.2%,42.9% and 2.9% among controls respectively.There was stati-stically significant difference between the two groups (χ²=6.40, P=0.04).Individuals with Gln/Gln genotype had a 3.6 5-fold increased risk of developing PTC compared to Arg/Arg genotype (OR=4.65,95% CI:1.24-17.45 ).The multivariate cond-itional logistic regression analysis showed that the XRCC1 Arg399Gln polymorphism, negative life events and X-irradiation history were associated with PTC,with odds ratios of 2.71(95%CI:1.22-6.05),5.34(95%CI:1.40-20.38) and 0.38(95% CI:0.12-0.72) respectively.However,XRCC1 Arg194Trp polymorphism, drinking tea,fruit and economic levels did not show statistically significant asso-ciations with PTC.Conclusion The Gln/ Gln genotype at XRCC1 Arg399Gln site and negative life events significantly increased wh-ile X-irradiation history decreased the risk of developing PTC.

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