| 叶冬青,胡以松,李向培,黄芬,杨仕贵,郝加虎,尹婧,张国庆,刘慧慧.系统性红斑狼疮发病的环境因素及其与几种趋化因子基因的交互作用[J].中华流行病学杂志,2004,25(11):949-953 |
| 系统性红斑狼疮发病的环境因素及其与几种趋化因子基因的交互作用 |
| Influences of environmental factors and interaction of several chemokines gene-environmental on systemic lupus erythematosus |
| 收稿日期:2003-12-04 出版日期:2014-09-17 |
| DOI： |
| 中文关键词: 系统性红斑狼疮 环境因素 非条件logistic模型 |
| 英文关键词: Systemic lupus erythematosus Environmental factors Unconditional logistic regression model |
| 基金项目:教育部科学技术研究重点项目资助(03056);国家自然科学基金(30371247);安徽省教育厅重点科研项目资助(2002kj175ZD);安徽省教育厅自然科学基金(2002kj166) |
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| 中文摘要: |
| 目的 探讨环境因素、日常生活方式、社会心理因素及其与-2518MCP-1、CCR2-64I、SDF1-3'A基因交互作用在系统性红斑狼疮(SLE)发病中的作用。方法 采用病例对照研究设计，用单因素和多因素非条件logistic模型分析影响SLE发病的因素，用非条件logistic模型分析基因-环境交互作用。结果 单因素logistic回归分析共发现19个因素与SLE发病有关，多因素logistic模型分析显示，有意义的变量共5个，其中饮井水为SLE的保护因素(OR=0.099)，而多种药物过敏(OR=8.174)、阳光过敏(OR=18.339)、服用抗生素(OR=5.626)、口服避孕药(OR=16.897)为SLE发病的危险因素。非条件logistic模型分析发现在SLE发病中好食刺激性食物与-2518MCP-1G/G基因型存在交互作用(OR=4.387)。未发现SLE发病中存在环境与环境的交互作用。结论 多个环境危险因素与SLE的发病有关，而且MCP-1基因与好食刺激性食物间存在交互作用。 |
| 英文摘要: |
| Objective To explore the impact of environmental factors, daily lifestyle, psycho-social factors and the interactions between environmental factors and ehemokines genes on systemic lupus erythematosus(SLE). Methods Case-control study was carried out and environmental factors for SLE were analyzed by univariate and multivariate unconditional logistic regression. Interactions between environmental factors and chemokines polymorphism contributing to systemic lupus erythematosus were also analyzed by logistic regression model. Results There were nineteen factors associated with SLE when univariate unconditional logistic regression was used. However, when multivariate unconditional logistic regression was used,only five factors showed having impacts on the disease, in which drinking well water (OR=0. 099)was protective factor for SLE, and multiple drug allergy(OR=8. 174), over-exposure to sunshine(OR=18.339), taking antibiotics(OR=9.630) and oral contraceptives were risk factors for SLE. When unconditional logistic regression model was used, results showed that there was interaction between eating irritable food and -2518MCP-1G/G genotype (OR=4.387). No interaction between environmental factors was found that contributing to SLE in this study. Conclusion Many environmental factors were related to SLE, and there was an interaction between - 2518MCP-1G/G genotype and eating irritable food. |
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