文章摘要
王洁,李小鹰,何耀,倪彬.老年周围动脉硬化闭塞病与血浆纤维蛋白原、血小板集聚率关系的研究[J].中华流行病学杂志,2005,26(1):1-4
老年周围动脉硬化闭塞病与血浆纤维蛋白原、血小板集聚率关系的研究
Study on the relationship of plasma f ibrinogen, platelet aggregation rate and peripheral arterial occlusive disease??
收稿日期:2004-04-28  出版日期:2014-09-15
DOI:
中文关键词: 周围动脉硬化闭塞病;血浆纤维蛋白原;血小板聚集
英文关键词: Peripheral arterial occlusive disease;Plasma fibrinogen;Platelet ag gregation
基金项目:
作者单位
王洁 武警总医院急诊科, 北京 100039 
李小鹰 解放军总医院老年心血管科, 北京 100039 
何耀 解放军总医院老年病研究所流行病室, 北京 100039 
倪彬 解放军总医院老年病研究所流行病室, 北京 100039 
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中文摘要:
      目的探讨血浆纤维蛋白原、血小板聚集对老年周围动脉硬化闭塞病(PAOD)的影响。方法在北京市万寿路地区20411名老年居民中,以家委会为单位整群随机抽样2121人,男941人,女1180人,最大年龄89岁,最小年龄60岁,平均年龄68.51岁±4.83岁。以踝动脉指数<0.9为PAOD诊断标准。以此诊断分成PAOD与非PAOD人群。在PAOD人群中抽取病例组232例,其中男73例、女159例,平均年龄70.97岁±6.46岁;在非PAOD人群中按完全随机方式抽取对照组464人,其中男217人、女247人,平均年龄68.63岁±5.29岁。病例组与对照组均化验血浆纤维蛋白原浓度,血小板最大聚集率及3min血小板聚集率。同时在两组中对PAOD患病有影响的因素进行多元logistic逐步回归分析。结果PAOD病例组血浆纤维蛋白原(435.45mg/dl±115.25mg/dl)高于对照组(360.96mg/dl±93.52mg/dl),P=0.001;3min血小板聚集率(48.76%±23.90%)高于对照组(43.50%±26.76%),P=0.012。logistic回归结果也显示血浆纤维蛋白原(OR=0.994,95%CI:0.992~0.994)及3min血小板聚集率(OR=0.578,95%CI:0.403~0.829)为对PAOD患病有显著影响意义的因素。结论PAOD患者中?
英文摘要:
      Objective?? To detect the relationship of plasma fibr inog en, platelet agg reg ation rate and peripheral arterial occlusiv e disease ( PAOD) in the elderly. Methods?? Cross??sectional survey for PAOD w as implemented. Two thousands one hundr ed twent y??one subjects aged 60??89 years, male 941, female 1180, means ag ed 68. 51?? 4. 83 years, w ere randomly selected out of 20 411 elderly residents w ithin 94 r esident ial communities on the Wanshoulu area, Beijing . Case gr oup involved 232 subjects, including 73 males and 159 females, w ith mean age 70. 97 ?? 6. 46 years, were randomly selected from the PAOD g roup on the PAOD cross??sectional study. 464 subjects w ere involved in the control group, including 217 males and 247 females, w ith mean age of 68. 63 ?? 5. 29, were randomly selected beyo nd the PAOD group on the PAOD cross??sectional study. Plasma fibrinogen level and platelet aggregation rate were determined in both g roups. T test between the two gr oups w as perfo rmed. The factors contributing to PAOD in t his study ( including: age, g ender, smoking, obesity , family history o f hypertension, diabetes, cor onary artery disease, stroke and triglycerides, cholesterol, high density lipoprotein, low density lipoprotein, plasma fibrinogen, platelet aggr egation rate) w ere performed using logistic regression analysis by diagnostic criter ia of PAOD in this study . Stepw ise selection was also used in this multiv ar iate regression analysis. Results Plasma fibrinogen level ( 435. 45 mg/ dl?? 115. 25 mg / dl) , w as higher in t he PAOD group than in the control group ( 360. 96 mg/ dl?? 93. 52 mg / dl, P= 0. 001 ) . Platelet aggregation rate at 3 minute ( 48. 76% ?? 23. 90%) in the PAOD group was higher compared with t he control group ( 43. 50% ?? 26. 76%) w ith P = 0. 012. Logist ic reg ression analysis show ed that factors, as plasma fibrinogen ( OR = 0. 994, 95% CI : 0. 992?? 0. 994) , platelet aggregation rate at 3 minute ( OR = 0. 578, 95% CI : 0. 403?? 0. 829) w er e independent r isk factors contr ibuting to PAOD in t his study. Conclusion?? Plasma fibrinogen lev el and platelet ag gregation rate w ere higher in the older patients of PAOD. It is possible for clinical physicians to inhibit platelet aggregation and reduce plasma fibr inog en level in the PAOD patients.
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