| 张霞芬,林志益.浙江省舟山市269例海岛渔民病毒性肝炎型别分析[J].中华流行病学杂志,2005,26(8):595 |
| 浙江省舟山市269例海岛渔民病毒性肝炎型别分析 |
| Study on the safety and immunogenicity of enterotoxigenic Escherichia coli recombinant active vaccine |
| 收稿日期:2005-03-28 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 肠毒素大肠埃希菌 疫苗 免疫性 |
| 英文关键词: Enterotoxigenic Escherichia coli Vaccine Immunogenicity |
| 基金项目: |
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| 中文摘要: |
| 为探讨海岛渔民病毒性肝炎的病毒种类及其与临床的关系, 对 269 例海岛渔民肝炎患者的型别进行了分析。研究对象为浙江省舟山市人民医院 2001 年 1 月至 2004 年 12 月住院的 269例渔民病毒性肝炎患者, 均为男性, 年龄18~ 65岁, 平均32. 5岁。 |
| 英文摘要: |
| Objective To study the safety, immunogenicity on the enterotoxigenic Escherichia coli(E.coli) recombinant active vaccine FE3 and FE16. Methods Toxicity and immunogenicity of the vaccine were determined by experiments on enterotoxigenic E.coli toxicity and immunological experiments on rabbits and mice. Results The results of an toxicological experiments were negative. The agglutination titer of antibodies against the S.flexneri 2a and enterotoxigenic E.coli plamid antigen were all higher than 1:640 and 1:1280 in the sera of rabbits. IgGin the serum went up remarkably, while sIgA against CFA/I was also decteted in the dejecta of mice immunized with active bacteria either orogastrically or intranasally. Simultaneously, sIgA was not detected in the dejecta of mice immunized with inactive bacteria either orogastrically or intranasally. Conclusion The enterotoxigenic E.coli recombinant active vaccine showed good safety and immunogenicity, inducing both humoral and mucosal immunity in mice. |
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