文章摘要
何寒青,陈坤,张扬,童峰,范春红,宋亮.谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析[J].中华流行病学杂志,2005,26(12):992-994
谷胱甘肽转移酶M1基因多态性与大肠癌发生关系的多水平Meta回归分析
Glutathione S-transferase M1 polymorphism and the risk on colorectal caner: a multilevel Meta regression
收稿日期:2005-05-30  出版日期:2014-10-16
DOI:
中文关键词: 谷胱甘肽转移酶M1基因;基因多态性;大肠肿瘤;Meta回归分析
英文关键词: Glutathione S-transferase M1;Genetic polymorphism;Colorectal neoplasms;Metaregression
基金项目:国家自然科学基金(30471492)
作者单位E-mail
何寒青 浙江大学医学院流行病学与卫生统计学教研室  
陈坤 浙江大学医学院流行病学与卫生统计学教研室 ck@zju.edu.cn 
张扬 浙江大学医学院流行病学与卫生统计学教研室  
童峰 浙江大学医学院流行病学与卫生统计学教研室  
范春红 浙江大学医学院流行病学与卫生统计学教研室  
宋亮 浙江大学医学院流行病学与卫生统计学教研室  
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中文摘要:
      目的 探讨谷胱甘肽转移酶(GST)M1基因多态性与大肠癌发生的关系及其影响因素。方法采用多水平Meta回归分析方法进行合并效应值估计和异质性相关因素的研究。结果GSTM1基因多态性与大肠癌发生有关(合并OR值为1.17.95%CI:1.08~1.26),种族类别、人群GSTM1基因基线缺失率等为研究间异质性的相关因素(P<0.05);分层回归中,亚洲人、高加索人及低基线缺失水平人群(50%以下)中的GSTM1基因缺失型是大肠癌发生的危险因素(合并OR值分别为1.14、1.25、1.29),结果具有统计学意义(P<0.05)。 GSTM1纯合缺失型是大肠癌发生的危险因素,并与人群的GSTM1基线缺失率和种族类别有关。
英文摘要:
      Objective In order to investigate the relationship between Glutathione S-transferase M1 (GSTMl) status and the risk on colorectal cancer as well as to detect the related factors to this association.Methods A pooled analysis of multilevel Meta-regression was performed to estimate GSTMl deficiency associated with the risks of colorectal cancer.Then subgroup Meta-regression was undertaken to evaluate the possible relationship between heterogeneity and the related characteristics.Results The overall pooled odds ratios of colorectal cancer risk associated with GSTM1 deficiency was 1.17(95% C7:l.08-1.26).Ethnicity, percent of GSTM1 deficiency in population had significant relationships with heterogeneity across the studies (P0.05).Results of subgroup Meta-regression showed that GSTMl deficiency was significantly associated with colorectal cancer risk in ethnic subgroups of Asians, Caucasians and in low level (lower than 50%) of GSTMl deficiency population( P 0.05).The respective pooled ORs were 1.14, 1.25 and 1.29.Conclusion GSTMl deficiency seemed to be a risk factor for colorectal cancer, while interactions on the characteristics of ethnicity, percentage of GSTMl deficiency in the studied population were related to this association.
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