文章摘要
王丽,林东昕,陆星华,缪小平,李辉.叶酸代谢相关基因MTHFR、MS基因多态与胰腺癌风险关联[J].中华流行病学杂志,2006,27(1):50-54
叶酸代谢相关基因MTHFR、MS基因多态与胰腺癌风险关联
Study on the relations between genetic polymorphisms in methylenetetrahydrofolate reductase,methionine synthase and the risk of pancreatic cancer
收稿日期:2005-04-05  出版日期:2014-09-12
DOI:
中文关键词: 胰腺癌;亚甲基四氢叶酸还原酶;甲硫氨酸合成酶;遗传易感性
英文关键词: Pancreatic cancer;Methylenetetrahydrofolate reductase;Methionine synthase; Genetic susceptibility
基金项目:卫生部临床重点学科资助项目(20010102)
作者单位
王丽 中国医学科学院基础医学研究所中国协和医科大学基础医学院流行病学教研室, 北京 100005 
林东昕 中国医学科学院肿瘤研究所病因与癌变研究室 
陆星华 北京协和医院消化内科 
缪小平 中国医学科学院肿瘤研究所病因与癌变研究室 
李辉 中国医学科学院基础医学研究所中国协和医科大学基础医学院流行病学教研室, 北京 100005 
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中文摘要:
      目的探讨亚甲基四氢叶酸还原酶(MTHFR)及甲硫氨酸合成酶(MS)基因多态与胰腺癌风险的关系。方法采用以医院为基础的病例对照研究(胰腺癌新发病例101例,对照337人)方法,进行MTHFRC677T、A1298C及MSA2756G基因多态与胰腺癌风险关联分析,采用PCR-RFLP方法进行两候选基因分型。结果携带MTHFR-677CT及TT基因型者发生胰腺癌风险是CC基因型个体的2.17(95%CI:1.26~3.85)及3.53(95%CI:1.85~6.84)倍,呈明显的等位基因-效应关系;未观察到MTHFR1298多态单独对胰腺癌发生的影响,但发现它与C677T有联合作用。MTHFR677CT与TT基因型与吸烟、饮酒有明显的正向交互,产生交互作用的ORint值分别为1.78(P=0.0010)和2.10(P=0.0051)。未发现MSA2756G多态与胰腺癌的发生之间存在统计学的显著关联。结论MTHFRC677T多态与胰腺癌发生风险显著关联,且与吸烟、饮酒存在正向交互作用。
英文摘要:
      ObjectiveTo determine whether genetic polymorphisms in methylenetetrahydrofolate reductase(MTHFR C677T and A1298C),methionine synthase (MS A2756G) were associated with the risks of pancreatic cancer. Methods A hospital2based,case2control study consisting of 101 incident pancreatic cancer cases and 337controls matched on age, sex and race was conducted to investigate the association between polymorphism in MTHFR and MS,and susceptibility to pancreatic cancer. Genotypes of MTHFR C677T,A1298C and MS A2756G were analyzed by polymerase chain reasction2restriction fragment length polymorphism methods.Results It wasfound that multivariate2adjusted odds ratio ( ORs ; 95 % confidence interval ) for MTHFR2677CT and 677TT compared with 677CC were 2. 17 (1. 2623. 85) and 3. 53 (1. 8526. 84) respectively,which was in a manner ofallele2dose relationship. However,no significant association between the A1298C genotype alone and the risk of cancer was observed which seemed that this polymorphism had a combined effect with the C677T polymorphism. A significant gene2environment interaction was observed between C677T polymorphism and cigarette smoking oralcohol intake. Subjects with variant genotypes who smoked > 17 pack2years had highest risk for developing the cancer,with the OR of 5. 58 (2. 53212. 30). Similarly, the OR (3. 27, 1. 5127. 23) for subjects with variant genotypes of alcohol drinker was significantly higher than that for subjects either having the variant genotype or being drinkers. No association was found between MS A2756Gpolymorphism and risk of pancreatic cancer in the study. Conclusion These findings supported the hypothesis that genetic polymorphisms in MTHFR C677T might contribute to the risk of developing pancreatic cancer.
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