文章摘要
谭纪萍,王鲁宁,王炜.老年人轻度认知功能损伤危险因素的病例对照研究[J].中华流行病学杂志,2006,27(1):55-57
老年人轻度认知功能损伤危险因素的病例对照研究
A case- control study of risk factors in mild cognitive impairment
收稿日期:2005-07-21  出版日期:2014-09-12
DOI:
中文关键词: 轻度认知功能损伤;危险因素;保护因素
英文关键词: Mild cognitive impairment;Risk factors;Protective factors
基金项目:军队“十五”医药科研重点基金项目资助(01Z2037)
作者单位
谭纪萍 解放军总医院南楼神经内科, 北京 100853 
王鲁宁 解放军总医院南楼神经内科, 北京 100853 
王炜 解放军总医院南楼神经内科, 北京 100853 
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中文摘要:
      目的探讨轻度认知功能损伤(MCI)的可能危险因素。方法采用病例对照研究,分析MCI以及年龄、性别和职业相匹配的认知功能正常老年人各97例和143例。结果单因素分析显示,冠心病、脑卒中和贫血病史以及受教育程度在两组之间差异有统计学意义;多因素分析去除了年龄的影响后,证实冠心病、脑卒中和贫血病史以及受教育程度与MCI显著相关,OR值(95%CI)分别为2.21(1.18~4.14)、2.18(1.20~3.98)、4.63(1.79~11.97)和0.75(0.58~0.97)。结论冠心病、脑卒中和贫血病史可能是MCI的独立危险因素,高教育水平是MCI的保护因素。
英文摘要:
      Objective To explore the risk factors of mild cognitive impairment (MCI ). MethodsA case- control study including 97 MCI patients and 143 cognitive normal controls( NC) in Chinese PLA GeneralHospital was conducted. The cases and controls were matched for age, gender and occupation. The relationship betweenMCI and various factors was analysed by univariate and multivariate analysis. Results Results data from univariate analysis showed that the history of coronary heart diseases, stroke, anaemia, and the education level hadsignificant differences between NC and MCI patients. Multivariate analysis confirmed that the history of coronary heart diseases, stroke, anaemia and the education level were significantly related to MCI and their OR s( 95%confidence interval) were 2. 21 ( 1. 18- 4. 14), 2. 18 ( 1. 20- 3. 98), 4. 63 ( 1. 79- 11. 97), 0. 75 ( 0. 58- 0. 97)respectively. ConclusionThe history of coronary heart diseases, stroke and anaemia were independent risk factors of MCI and high education level seemed to be a protective factor of MCI.
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