文章摘要
朱红,王建华.2型糖尿病并发肺结核病的危险因素探讨[J].中华流行病学杂志,2006,27(1):58-62
2型糖尿病并发肺结核病的危险因素探讨
Risk factors for the development of pulmonary tuberculosis among type 2 diabetes mellitus patients
收稿日期:2005-03-28  出版日期:2014-09-12
DOI:
中文关键词: 糖尿病,2型;肺结核病;危险因素
英文关键词: Diabetes mellitus,type 2;Pulmonary tuberculosis;Risk factor
基金项目:国家自然科学基金资助项目(30371248)
作者单位
朱红 天津医科大学公共卫生学院流行病学教研室 300070 
王建华 天津医科大学公共卫生学院流行病学教研室 300070 
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中文摘要:
      目的探讨2型糖尿病并发肺结核病(DM-PTB)的危险因素。方法对2001年10月至2002年10月收集的87例新发DM-PTB患者和同期129例单纯2型糖尿病患者进行成组病例对照研究,采用经因子分析改进后的多因素非条件logistic回归模型探索DM-PTB的危险因素。结果不良接触因子、糖尿病病情重、不良习惯因子及食盐摄入量少可增加DM-PTB的发生危险,其比值比(OR)和95%可信区间(95%CI)分别为1.778 (1.248~2.534)、 1.749 (1.221~2.506)、1.614(1.136~2.294)和1.586(1.119~2.248),而良好习惯因子、社会经济地位高、高血压、居住条件好及患糖尿病后饮食控制好可降低DM-PTB的发生危险,其OR值和95%CI分别为0.333(0.218~0.508)、 0.508(0.346~0.745)、 0.517(0.350~0.764)、0.599(0.413~0.868)和0.630(0.447~0.889)。结论不同性别和年龄的2型糖尿病患者易并发肺结核病的危险因素或保护因素不同,应针对不同人群制定不同的防治策略。
英文摘要:
      ObjectiveTo explore risk factors for pulmonary tuberculosis among type 2 diabetes mellitus patients(DM2PTB). Methods A hospital2based case2control study was conducted at three hospitals in Tianjinduring October 2001 to October 2002. 87 newly2diagnosed PTB patients with type 2 DM were recruited as cases,and 129 type 2 DM patients were chosen as controls. Information on risk factors was collected through face2to2face interview. Univariate unconditional logistic regression model and multivariate logistic regression modified by the factor analysis were conducted to explore the risk factors for DM2PTB and final main effect functions were built byage and sex. Results 31 variables were found to be associated with DM2PTB in the univariate analysis. The modified multivariate logistic regression analysis found that bad contact factor ( OR = 1. 778, 95 % CI : 1. 24822. 534), severe state of DM( OR = 1. 749,95 % CI : 1. 22122. 506), bad habits factor ( OR = 1. 614, 95 % CI :1. 13622. 294) and low intake of salt ( OR = 1. 586, 95 % CI : 1. 11922. 248) were generally associated with increased risk of DM2PTB in the final model ; while factors as good habits ( OR = 0. 333, 95 %CI :0. 21820. 508),high socioeconomic level ( OR = 0. 508, 95 % CI : 0. 34620. 745), hypertension ( OR = 0. 517, 95 % CI : 0. 35020. 764), good housing condition ( OR = 0. 599, 95 % CI :0. 41320. 868) and beneficial change of diet after DM(OR = 0. 630, 95 %CI : 0. 44720. 889) were shown to be reversely associated withDM2PTB. ConclusionDifferent genders and different ages have different risk factors or protective factors. Thus, to reduce theprogressively increased incidence of PTB among DMpatients, preventive strategies and measures should be focused on the most vital predisposing factors in corresponding risk populations
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