| 李敬云,李林,李宏,鲍作义,李韩平,王哲,庄道民,刘永健,刘思扬.中国中部农村艾滋病病毒感染状况不一致夫妻的随访研究[J].中华流行病学杂志,2006,27(3):192-195 |
| 中国中部农村艾滋病病毒感染状况不一致夫妻的随访研究 |
| Cohort study on human immunodef iciency virus discordant couples in the countryside of central China |
| 收稿日期:2005-09-01 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 艾滋病病毒 异性性传播 艾滋病病毒感染状况不一致夫妻 |
| 英文关键词: Human immunodeficiency virus Heterosexual transmission Human immunodeficiency virus discordant
couples |
| 基金项目:国家“十五”科技攻关资助项目(2004BA719A01) |
|
| 摘要点击次数: 2882 |
| 全文下载次数: 1022 |
| 中文摘要: |
| 目的 在河南省某地农村建立艾滋病病毒(HIV)感染状况不一致(DC)的夫妻队列并进行随访, 观察HIV通过异性性传播的频率及其影响因素。方法 通过访谈和血清学检测, 确定了52对(一方HIV阳性而另一方阴性但无吸毒、性乱、输血等HIV感染危险行为)夫妻进入研究队列, 在0.5、1和2.5年进行3次随访, 每次随访均询问夫妻双方的性生活和安全套使用情况, 同时抽取20ml抗凝静脉血检测HIV抗体、CD4+T淋巴细胞计数以及病毒载量。结果 (1)0.5、1和2.5年的随访率分别是92.3%、75.0%和28.8%。在随访的过程中, DC夫妻中HIV阴性一方HIV抗体始终保持阴性, 未出现HIV抗体阳转及HIV的传播。 (2)在队列建立时(0年)以及0.5、1和2.5年随访时, DC夫妻性生活次数每月1次至每周1次的分别占65.4%、72.9%、71.7%和80.0%, 有时使用或从来不用安全套的比例分别是76.9%、66.6%、69.1%和60.0%, 不同随访时间性生活次数和安全套使用频率的差异无统计学意义。(3)DC夫妻中的HIV阳性一方在0.5、1和2.5年随访时,CD4+T淋巴细胞计数保持稳定或上升的比例分别是85.4%、66.6%和60.0%。15对在2.5年随访到双方的夫妻,HIV阳性一方中病毒载量稳定和下降的占66.7%, 绝大部分病毒载量保持稳定或下降者同时CD4+T淋巴细胞计数也保持稳定或上升。 结论 研究中未观察到HIV在夫妻之间的传播。HIV阳性一方稳定的病毒载量和CD4+T细胞计数可能是HIV未发生传播的原因之一, 宿主的遗传免疫学因素以及HIV的生物学特性对传播的影响值得深入研究。 |
| 英文摘要: |
| Objective To establish a cohort of human immunodeficiency virus ( HIV) discordant
couples for follow-up studies and to collect data on frequency of HIV heterosexual transmission and related
factors. Methods A total of 52 HIV discordant couples were identified by face to face interview and
serological testing,in which the HIV negative individuals had no HIV infection behaviors including injecting
drug use,blood transfusion or having sexual partners other than his/her own wife/husband. Three times of
follows-up studies were carried out in 0.5 year,1 year and 2.5 years to collect information on their sexual
practices and condom use through face to face interview together with 20 ml whole blood collected to test
HIV antibody,CD4+T cell count and viral load. Results (1) In the period of 2.5 years follow-up,no HIV
seroconversion and HIV transmission was found. (2) The frequencies of sexual intercourse between once
per month to once per week were 65.4 %,72.9%,71.7 % and 80.0% at the time of cohort setup : 0.5
year,1 year and 2. 5 years of follow2up respectively. The rates of“occasional use”to“never use”condoms
were 76.9%,66.6%,69.1% and 60.0% at the time of cohort setup as : 0.5 year,1 year and 2.5 years of
follow2up,respectively. No significant difference between different times of follow2up for sexual intercourse
or condom use. (3) 85.4%,66.6% and 60.0% of the HIV positive individuals kept their CD4+T cell
count stabilized or raised during the 0.5 year, 1 year and 2. 5 years follow-up period, respectively.
Howedver, 66.7% of them showed stable or declined viral load in the period of 2.5 years follow-up. It appeared that stable or raised CD4+T cell and the stable or declined viral load happened simultaneously. Conclusion No
transmission was identified in this study. The stabilized CD4+T cell count and viral load might be account for the reason of
no transmission while the biological factors from host and virus related with transmission need to be further studied. |
|
查看全文
Html全文
查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
|
|
|
