| 尹潞,秦光明,阮玉华,张莉,郝沁宁,陈显煌,姜正清,宋本莉,刘石柱,曹晓蕴,郝春,陈康林,邵一鸣.四川省吸毒人群艾滋病病毒和梅毒新发感染的队列研究[J].中华流行病学杂志,2006,27(4):293-297 |
| 四川省吸毒人群艾滋病病毒和梅毒新发感染的队列研究 |
| A prospective cohort study on human immunodeficiency virus and syphilis seroconversion among injecting drug users |
| 收稿日期:2005-11-25 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 艾滋病病毒 梅毒 静脉吸毒人群 前瞻性队列研究 |
| 英文关键词: Human immunodeficiency virus Syphilis Injecting drug users Prospective cohort |
| 基金项目:国家“十五”科技攻关课题项目(2004BA719A01 2004BA719A02);卫生部艾滋病防治应用性研究项目(WA2003-13);国家自然科学基金资助项目(30571612 10501052) |
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| 中文摘要: |
| 目的调查四川省某地区静脉吸毒人群艾滋病病毒(HIV)和梅毒血清抗体阳转情况及其危险因素。方法 2002年11月在四川省西昌市以社区为基础招募HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,在队列每6个月随访时调查静脉吸毒人群高危吸毒行为和性行为情况, 并采集血样进行HIV和梅毒抗体检测。结果队列随访2年,静脉吸毒人群队列保持率和HIV血清抗体阳转率分别为75．7%和2．53/100人年(95%CI:1．10-3．97),在多因素Poisson回归模型分析中,民族(RR=12．42,95%CI:2．72-56．74,P=0．0012)、近3个月共用针头或注射器(RR=4．06, 95%CI:1．29-12．81,P=0．0168)与HIV血清抗体阳转的关系有统计学意义。该研究队列梅毒血清抗体阳转率为4．71/100人年(95%CI:2．59-6．82),在多因素Poisson回归模型中,女性(RR= 4．42,95%CI:1．78-10．99,P=0．0014)与梅毒血清抗体阳转的关系有统计学意义。结论该地区静脉吸毒人群HIV和梅毒新发感染率高,应采取有效的干预措施以控制HIV的传播流行。 |
| 英文摘要: |
| Objective To study the rate of human immunodeficiency virus(HIV) seroconversion, HIV transmission and related risk factors among injecting drug users(IDUs) in an area of Sichuan province. Methods In November 2002, a community-based baseline survey was conducted to recruit 333 HIV-seronegative IDUs for a prospective cohort study in Xichang county of Sichuan province, China. Follow-up visits were carried out every 6 months to study the situation of drug use, sexual behaviors of the IDUs and blood specimens were collected to test for antibodies against HIV and syphilis. Results During a 24-month follow-up period, cohort retention rate and HIV incidence were 75.7% and 2.53 per 100 person-years [95% confidence interval(CI) : 1.10-3.97)], respectively. Multivariate Poisson regression model showed that risk factors which were significantly associated with HIV seroconversion would include: ethnicity (RR=12.42; 95%CI: 2.72-56.74, P=0.0012) and needle or syringe sharing in the past 3 months (RR=4.06; 95%CI: 1. 29-12.81,P = 0.0168). Syphilis seroconversion in this cohort was 4.71 per 100 person-years (95% CI:2. 59-6.82). In multivariate Poisson regression being female (RR = 4.42; 95% CI:l.78-10.99, P= 0.0014) appeared to be the only factor which was significantly associated with syphilis seroconversion. Conclusion Our study results showed that there was a rapid transmission of HIV and syphilis among IDUs in Sichuan province, suggesting that effective intervention should be urgently taken. |
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