| 祁芝珍,戴二黑,周冬生,杨永海,于守鸿,戴瑞霞,赵海红,李敏,杨瑞馥.青海省2004年人间鼠疫分离株基因分型及流行病学意义[J].中华流行病学杂志,2006,27(4):316-318 |
| 青海省2004年人间鼠疫分离株基因分型及流行病学意义 |
| A molecnlar epidemiological study on human plague fulminant epidemic in Qinghai, 2004 |
| 收稿日期:2005-11-24 出版日期:2014-10-17 |
| DOI： |
| 中文关键词: 鼠疫 鼠疫菌 基因分型 流行病学 |
| 英文关键词: Plague Yersinia pestis Genotyping Epidemiology |
| 基金项目: |
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| 中文摘要: |
| 目的探讨鼠疫耶尔森菌(鼠疫菌)基因分型在鼠疫暴发中的流行病学意义。方法根据已经证实的23个差异区段设计引物,对2004年青海省人间鼠疫流行期间分离到的13株鼠疫菌进行PCR扩增。结果 13株鼠疫菌可分为4个基因组型,即Genomovar 8、10、15和16。其中囊谦的8 株菌全部为Genomovar 10;乌兰的2株菌分别为Genomovar 8和15;祁连、曲麻莱、称多的3株鼠疫菌的基因组型均为Genomovar 16。结论鼠疫菌基因分型是鼠疫疫情暴发流行病学调查的有力工具。 |
| 英文摘要: |
| Objective To study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004. Methods Primer pairs targeting the twenty-three different identified regions(DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia pestis isolated from the fulminant epidemic of human plague in Qinghai province in 2004. Results There were 4 genomovars,i.e. Genomovar 8,10,15 and 16 in the 13 strains of Yersinia pestis identified. The genomovar of all the strains of Yersinia pestis isolated from Nangqian county was Genomovar 10. Among the two strains of Yersinia pestis isolated from Wulan county, the genomovar of one strain was Genomovar 8 and the other was Genomovar 10. The genomovars of all the strains of Yersinia pestis isolated from Qilian, Qumalai and Chengduo county belonged to Genomovar 16. Conclusion It was demonstrated that the genotyping of Yersinia pestis appeared to be a powerful tool for investigating human plague epidemics. |
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