文章摘要
陈春富,郎森阳,贾海燕,夏程,王湘庆.癫痫持续状态患者发生多器官功能障碍的危险因素分析[J].中华流行病学杂志,2006,27(7):618-622
癫痫持续状态患者发生多器官功能障碍的危险因素分析
Analysis on the risk factors regarding multiple organ dysfunction syndrome in patients with status epilepticus
收稿日期:2005-12-02  出版日期:2014-09-12
DOI:
中文关键词: 癫痫  全身惊厥性癫痫持续状态  多器官功能障碍  危险因素  非条件logistic回归分析
英文关键词: Epilepsy  Ueneralized convulsive status epilepticus  Multiple organ dysfunction syndrome  Risk factors  Nonconditional logistic analysis
基金项目:
作者单位
陈春富 煤炭总医院神经内科, 北京 100028 
郎森阳 解放军总医院神经内科 
贾海燕 煤炭总医院神经内科, 北京 100028 
夏程 解放军总医院神经内科 
王湘庆 海军总医院神经内科 
摘要点击次数: 2626
全文下载次数: 1327
中文摘要:
      目的分析成年人癫痫持续状态患者中发生多器官功能障碍(MODS)的危险因素。方法1988-2004年连续住院的317例全身惊厥性癫痫持续状态(GCSE)患者,其中资料完整的共137例。疾病组为41例癫痫持续状态继发MODS的患者,对照组96例为同期住院未发生MODS的癫痫持续状态患者。病例和对照采用统一的调查表,用Microsoft Access 2003建立数据库,共53个主项内容,部分主项设有下属分项。对研究资料先进行单因素分析,然后进行多因素非条件logistic回归模型分析。结果经分析筛选出癫痫状态持续时间(OR=14.965)、GCSE持续抽搐发作类型(OR=3.836)、GCSE治疗时机(OR=2.404)、持续发热(OR=1.539)、年龄(OR=1.324)等5个因素为癫痫持续状态继发MODS的独立危险因素。结论癫痫状态继发MODS与抽搐持续时间、GCSE持续抽搐发作类型、治疗时机关系最为密切,持续发热、患者高龄也可促发MODS。
英文摘要:
      Objective The purpose of this study was to evaluate the risk factors responsible for multiple organ dysfunction syndrome (MODS) in adult patients with status epilepticus. Methods The authors retrospectively reviewed the medical records of 317 patients admitted to Department of Neurology at hospitals from April 1988 to December 2004 with the diagnosis of generalized convulsive status epilepticus (GCSE). Of these patients, 137 had detailed and complete documents of case history. Forty-one patients with MODS following GCSE were compared with 96 controls without MODS after GCSE. All of them were inpatients in the same period. Based on a standardized questionnaire,a database was set using the Microsoft Access 2003 with data including 53 indexes and some subindexes. Nonconditional multivariate stepwise logistic regression was made after univariate analysis.Odds ratio(OR) and 95% confidence interval after adjustment for possible confounding variables were calculated. Results Five parameters emerged as significant independent predictors of MODS induced by GCSE in adults in multiple logistic regression which including duration of seizures during GCSE (OR=14.965), GCSE with continuous seizure activity (OR=3.836), time interval between the onset of GCSE and starting therapy (delay in SE treatment) (OR =2. 404), persistent fever (OR =1.539) and older age (OR= 1. 324). Conclusion Duration of seizures during GCSE, GCSE type of continuous seizure activity and delay in treatment for GCSE were indicators, which independently associated with a higher likelihood of MODS following GCSE in adults. Persistent fever and older age seemed to be independent predictors of a higher risk of MODS after GCSE.
查看全文   Html全文     查看/发表评论  下载PDF阅读器
关闭