| 李艳萍,李荣成,方孔雄,李河民,胡忠玉,何鹏,吴小音,张瑞,梁争论,庄辉.广西壮族自治区隆安县乙型肝炎疫苗全程接种后的免疫记忆研究[J].中华流行病学杂志,2007,28(4):319-321 |
| 广西壮族自治区隆安县乙型肝炎疫苗全程接种后的免疫记忆研究 |
| Studies on the status of immune memory after completion of hepatitis B vaccination |
| 收稿日期:2007-02-01 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 乙型肝炎病毒 免疫记忆 加强免疫 |
| 英文关键词: Hepatitis B virus Immune memory BOOster immunization |
| 基金项目:国家“十五”科技攻关课题资助项目(2004BA718802) |
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| 中文摘要: |
| 目的<\b> 了解接种全程乙型肝炎(乙肝)疫苗后的免疫记忆情况.方法<\b> 1987-1989年出生时接种乙肝血源疫苗的1201名新生儿,以及1996-1999年出生时接种乙肝酵母重组疫苗的2484名新生儿,于2005年随访时检测乙肝表面抗原(HBsAg)、表面抗体(抗-HBs)和核心抗体(抗-HBc),结果<\b>959名3项乙肝病毒(HBV)标志物均阴性,其中228名接种乙肝血源疫苗,731名接种乙肝酵母重组疫苗,于加强免疫1针乙肝酵母重组疫苗后15 d时检测其抗-HBs.此外,随机选择11名加强免疫后无应答和22名有应答者,应用酶免疫斑点法(ELISPOT)测定白细胞介素-2(IL-2).有初次免疫后抗-HBs定量检测资料者190名,比较其初次免疫和加强免疫后抗-HBs水平.结果<\b> 加强免疫后,79.82%接种乙肝血源疫苗者抗-HBs阳转,几何平均滴度(GMT)为325.69 mIU/ml;95.62%接种乙肝酵母重组疫苗者抗-HBs阳转,GMT为745.18 mIU/ml.加强免疫后所产生的抗-HBs水平与初次免疫后抗体滴度有关.加强免疫后抗-HBs阳转者的IL-2阳性率(40.91%)也高于无应答者(P＜0.01).结论<\b> 在乙肝疫苗初次免疫后,抗-HBs转阴者中,大部分仍具有免疫记忆,仅少部分在长期随访中丧失免疫记忆.因此,在高流行地区,对丧失免疫记忆者应进行乙肝疫苗加强免疫。 |
| 英文摘要: |
| Objective<\b> To study the immune memory in vaccinees after the completion of a full
schedule heDatitis B immunization.Methods<\b> One thousand and two hundred one infants born in 1987-1989 were immunized with 3 doses of plasma derived hepatitis B vaccine，while 2484 newbom babies during 1996-1999 were injected with 3 doses of the yeast recombinant hepatitis B vaccine.All of the infants under observation were tested for HBsAg，anti-HBs and anti-HBc，in 2005.Of 959 individuals negative for anti-HBs(<10 mIU／m1)，HBsAg and anti-HBc，228 were immunized with plasma-derived vaccine and 731 with veast recombinant vaccine after birth.A1l of them were detected for anti一HBs 15 days after a booster of 10 μg yeast recombinant vaccine.In addition，interleukin一2(IL一2)was detected in 11 non-responders and 22 responders after boostering，using an enzvme-linked immunospot(ELISPOT).The anti。HBs levels of 190 individuals(91 with Dlasma derived vaccine and 99 with yeast recombinant vaccine)who had had
quantitative data on their antibody status after the primary hepatitis B vaccination，were compared with that after the boostering.Results<\b> Among the individuals who received plasma derived vaccine 16-18 years ago，79.82％of them showed the signs of immune memory after one booster，with a geometric mean titer (GMT)of 325.69 mIU／mI.Of the individuaIs who received the yeast recombinant vaccine 6-9 vears ago，95.62％showed immune memorv after one booster，with its GMT of 745.18 mIU／m1.Anti-HBs levels induced by the booster were associated with that after the primary immunization.The positive rate of IL一2 was 40.91％in subiects with good immune memory.However，IL一2 was not detected in rlon-responders after the booster(P<0.01).Conclusion<\b> IⅥost of the individuals who had received a completed schedule of primary hepatitis B vaccination and seroconverted from anti-HBs positive to negative，showed the signs of having immune mcmorv after the b00ster.0nly a small proportion of the vaccinees had lost their immune memory during the 10ng term fonow-up period，suggesting that these individuals should receive a booster of hepatitis B vaccine in the highlv endemic areas of hepatitis B. |
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