| 吴疆,张卫,韩莉莉,林长缨,林晖,邢玉兰,高培,龚晓红,刘立荣,黄芳,刘健英,刘利英,王化勇,于海柱,刘秀军,唐雅清,蒲永兰,赵伟,王晨,张震,马立宪.北京市人群乙型肝炎血清流行病学研究[J].中华流行病学杂志,2007,28(6):555-557 |
| 北京市人群乙型肝炎血清流行病学研究 |
| A sero_epidemioIogical study on hepatitis Beijing general populatio in Beijing |
| 收稿日期: 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 乙型肝炎病毒 血清流行病学研究 流行率 自然人群 |
| 英文关键词: Hepatitis B virus Seroepidemiologic study Prevalence mte General population |
| 基金项目: |
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| 中文摘要: |
| 目的探讨北京市人群乙型肝炎(乙肝)病毒(HBv)血清学感染状况。方法在北京全市范围内, 按照多阶段整群随机抽样的方法调查1岁以上各年龄组自然人群, 对每名对象乙肝疫苗接种情况以及主要危险因素进行问卷调查。采集每名对象静脉血, 利用雅培微粒子酶免疫分析法检测HBV五项血清学指标。结果乙肝HBSAg、抗一HBs、抗.HBc阳性率以及HBV总感染率分别为3.49%(95%CI:2.99～3.99), 37.79%(95%CI:36.46～39.12), 35.04%(95%CI:33.72～36.35), 35.09%(95%CI:33.78～36.40);年龄标化率分别为3.02%、42.47%、26.86%和26.90%。结论北京市5岁以下儿童HBsAg流行率已降至1%以下, 全人群HBsAg阳性率已经降至4%以下。 |
| 英文摘要: |
| Objective to explore the serological infection rate of hepatitis B virus(HBV)in general population aged over one year old in Beijing and to provide information for contro1 and prevention of the Disease Methods A multistage randomized cluster sampling was carried out in general population of Beijing, aged over one year old. Every study subject’s hepatitis B immunization history and main risk factors were investigated through questionnaire. Venous blood samples were collected and then tested for five hepatitis B serological antigens and antibodies by means of Abbott Microparticle Enzyme Immunoassy method.Results The prevalence rates of HBsAg, anti-HBs, anti-HBV and total HBV infection rate were 3.49%(95%CI:2.99-3.99), 37.79%(95%CI:36.46-39.12), 35.04%(95%CI:33.72-36.35)and 35.09%(33.78-36.40)respectively.The age standardized rates were 3.02%, 42.47%, 26.86%and26.90%respectively.Conclusion Achievement in hepatitis B contr01 and prevention was made in Beeijing since the prevalence rate of hepatitis B surface antigen had been below 1% for children aged less than 5 years old.As for the general population, the prevalence rate of hepatitis B surface antigen had reduced to less than 4%. |
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