文章摘要
郭志荣,胡晓抒,陈冯梅,武鸣.C反应蛋白水平与传统冠心病危险因素分析[J].中华流行病学杂志,2007,28(11):1064-1068
C反应蛋白水平与传统冠心病危险因素分析
Study On C-reactive protein and the risk factors of traditional coronary heart disease
投稿时间:2007-03-12  
DOI:
中文关键词: 冠心病;c反应蛋白;危险因素
英文关键词: Coronary heart disease;C-reactive protein;Risk factors
基金项目:
作者单位
郭志荣 苏州大学放射医学与公共卫生学院, 215123 
胡晓抒 江苏省疾病预防控制中心 
陈冯梅 苏州大学放射医学与公共卫生学院, 215123 
武鸣 江苏省疾病预防控制中心 
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中文摘要:
      目的了解江苏省人群c反应蛋白(cRP)的水平与传统冠心病(cHD)危险因素的关系。方法通过“江苏省多代谢异常和代谢综合征综合防治研究”资料,比较高敏c反应蛋白(hs-CRP)(hS-CRP:l,~2.99 mg/L和≥3 mg/L)与传统CHD危险因素:体重指数(BMI)、吸烟、高血压、高血糖、高胆固醇、高三酰甘油、低高密度脂蛋白胆固醇、体力活动缺乏等的关系。结果高hs-CRP罹患率均随血压、血糖、胆固醇、三酰甘油、BMI、吸烟、体力活动(无、轻、中、重)增加而增高,但当hs.CRP(1~2.99 mg/L)时,传统CHD危险因素中大部分未表现出显著联系;随着Framingham心脏积分(5个危险因素)合并数量增加,高hs-cRP呈明显的等级性变化趋势;logistic回归分析表明,hs-CRP(≥3 mg/L)时,BMI、三酰甘油、高血压、高密度脂蛋白胆固醇、吸烟、血糖的0R值均有统计学意义,但hs-cRP(1~2.99 mg/L)时,传统cHD危险因素的oR估计值大部分无统计学意义;男性中60.98%和女性中59.02%的高CRP可以归因于传统cHD危险因素。结论传统cHD危险因素与hs-CRP水平关系密切,目前在临床上、人群研究中根据CRP水平的高低判断CHD风险的实际意义值得进一步探讨。
英文摘要:
      objective To ascertain the relationship between C-reactive protein(hs-cRP)and“skfactors of traditional cor。nary heart disease(CHD)in a sampled population from Jiangsu province of China.methods Using data derived from a proiect on multiple metabolic disorders and metab01ic syndrome inJiangsu province,a cross-sectional study was car“ed out.Criteria was set as:CRP level categories from 1 to2.99 mg/L,and greater than 3 mg/L,t。explore the relationship between different category of cRP andrisk factors of traditional coronary heart disease which would include body mass index(BⅣII), cigarettesmoking,high bl∞d pressure, bl∞d glucose, total c}101esterDl level, triglyceride (TG), high-densitylipoprotein cholesterol(HDL-C) level, physical activity etc. results The attack rate of high CRPincreased with the degree of risk factors related to traditional coronary heart disease. However, whenhs-CRP fell between 1-2.99 mg/L, part of the traditional risk factors would display significance.Significance increased in high CRP related to grading was observed across the Framingham heart score(quintiles).Data frOm the logistic regression analysis sh。wed that:when hs*cRP(≥3 mdL),theoR ofBMI, TG, high bl∞d pressure, HDL-C, cigarette smoking, blo。d glucose all appeared statisticalsignificance whereas hs。CRP between 1-2.99 mg/L,the O尺of trationaI CHD“sk factors did not showstatistical significance but 60.98% of the males and 59.02% of the females would have high hs-CRPincriminate traditional CHD risk factors.ConcIusion As the close relationshiD between traditional CHDrisk factors and hs.CRP was seen,the role of hs-CRP in estimating the risk of CHD was limited,despitethe origin of data,either from clinical or from cohort study.
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