文章摘要
孙佳艺,赵冬,王薇,刘静,成君,刘军,李岩,贾妍娜.北京地区45~74岁人群高敏C反应蛋白水平与代谢综合征及其组份的关系[J].中华流行病学杂志,2007,28(12):1155-1158
北京地区45~74岁人群高敏C反应蛋白水平与代谢综合征及其组份的关系
Distributions of high-sensitivity C-reactive protein and its association with metabolic syndrome in population aged 45-74 in Beijing
收稿日期:2007-08-17  出版日期:2014-09-12
DOI:
中文关键词: 代谢综合征;高敏C反应蛋白;心血管病
英文关键词: Metabolic syndrome;High-sensitivity C-reactive protein;Cardiovascular disease
基金项目:1.北京市心血管病高技术实验室资助项目 2.北京市科技新星计划项目
作者单位
孙佳艺 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
赵冬 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
王薇 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
刘静 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
成君 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
刘军 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
李岩 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
贾妍娜 首都医科大学附属北京安贞医院流行病研究室北京心肺血管疾病研究所 100029 
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中文摘要:
      目的描述北京地区45~74岁人群高敏C反应蛋白(hs-CRP)水平的分布特点,分析hs-CRP与代谢综合征(MS)及其各组份间的关系.方法于2002-2004年对北京地区45~74岁人群进行心血管病危险因素检查,并加入了hs-CRP指标.对资料完整的1544人进行分析.MS诊断采用NCEP-ATPⅢ修订后的标准.结果(1)北京地区45~74岁人群hs-CRP水平的中位数为1.00 mg/L,几何均数为(0.79±9.59)mg/L.hs-CRP水平随年龄的增长呈增加趋势(P<0.05),男女两性间的差异无统计学意义(P>0.05).(2)将hs-CRP按四分位进行分层后,随hs-CRP水平的增加,MS患病率也增加且呈线性趋势(P<0.01),在hs-CRP最高四分位组,血压异常所占的比例最高(74.6%),其次为腹部肥胖(71.7%).单因素分析显示:hs-CRP最高四分位组患MS的危险是最低四分位组的6.77倍.在调整了年龄、性别、吸烟和饮酒后,多因素logistic回归分析显示:以hs-CRP最低四分位组为参照,hs-CRP最高四分位组发生MS各组份异常的危险均增加,其患MS的危险是最低四分位组的6.35倍.结论hs-CRP水平随年龄的增长而增加,且与MS各组份异常密切相关.
英文摘要:
      ObjectiveTo describe the distributions of high-sensitivity C-reactive protein (hs-CRP) and its association with metabolic syndrome (MS) in population aged 45-74 in Beijing.MethodsA population-based cross-sectional survey was conducted in Beijing during 2002-2004 and the component of MS and plasma hs-CRP concentration were assessed.Analysis was performed in a total of 1544 subjects with completed information.Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment PanelⅢcriteria for Asian Americans.ResultsThe median and geometric mean concentrations of hs-CRP among our study population were 1.00 mg/L and 0.79 mg/L, respectively,bs-CRP level showed an upward trend with increased age (P0.05) but no statistically significant difference of hs-CRP levels between genders was observed (P0.05).The prevalence of MS progressively increased with elevated hs-CRP quartiles (P0.01).The prevalence rates of hypertension and central obesity were substantially higher in the highest quartile of hs-CRP levels than those in the lowest quartile.In a univariate logistic regression analysis,the risk for MS was higher in the highest quartile of hs-CRP than that in the lowest quartile.After adjusting for age,sex,smoking and drinking,the highest quartile of hs-CRP was found to be independently associated with each component of MS and 6.35- fold increased risk of MS.ConclusionThe hs-CRP level appeared to be increased with age and correlated to all the components of MS.
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