| 何耀,姜斌,万志恒,郑强荪,李兰荪,李良寿.被动吸烟对不吸烟女性血脂和血液流变学指标的影响[J].中华流行病学杂志,2007,28(12):1167-1170 |
| 被动吸烟对不吸烟女性血脂和血液流变学指标的影响 |
| Study on the relationship between passive smoking and blood lipids, fibrinogen and viscosity among women who never smoke |
| 收稿日期:2007-06-28 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 吸烟 血脂 纤维蛋白原 冠心病 |
| 英文关键词: Passive smoking Blood lipids Fibrinogen Coronary heart disease |
| 基金项目:教育部留学回国人员科研启动基金 |
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| 中文摘要: |
| 目的在不吸烟女性中探讨被动吸烟对血脂、纤维蛋白原和血液黏度的影响.方法在115例冠心病患者(其中52例经冠脉造影确诊)和208名非冠心病者为对照组(83名经冠脉造影排除)中采用国际标准的质控血清进行血脂组分,即血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及亚组分HDL2-C、载脂蛋白(apo)A1和apoB、纤维蛋白原和血液黏度的测定.被动吸烟暴露的定义是与吸烟的丈夫或同事接触至少5年.结果在冠脉造影确诊者中被动吸烟者的血脂紊乱、血浆纤维蛋白原水平和血浆黏度的升高较非被动吸烟史者更为严重,且与冠脉病变程度呈正相关.在非冠心病对照组中,127例被动吸烟者与81例非被动吸烟暴露者各变量的调整(年龄、体重指数、既往病史)均值的差异检验P值分别为:TC 0.06、TG 0.30、HDL-C 0.004、HDL2-C＜0.001、apoA1＜0.001、apoB 0.009、apoB/apoA1＜0.001、纤维蛋白原＜0.001、血浆＜0.001及全血的低高两个切变率黏度＜0.001和0.004.被动吸烟量与HDL-C、HDL2-C、apoA1、apoB、apoB/apoA1、纤维蛋白原、血浆及全血的高低两个切变率黏度的多元相关系数分别为-0.25、-0.27、-0.30、0.24、0.31、0.32、0.43、0.51和0.36(P值均＜0.01).结论无论生理或病理状态下,被动吸烟均可导致机体脂代谢紊乱、血浆纤维蛋白原和血液黏度的升高. |
| 英文摘要: |
| ObjectiveTo determine whether blood lipids profile,fibrinogen and viscosity were associated with passive smoking (i.e.environmental tobacco smoke,ETS) in Chinese women who never smoke.MethodsIn Xi'an,China,a case-control study was carried out on 115 cases of coronary heart disease (CHD) defined by coronary arteriography (CAG) and 208 non-CHD controls confirmed by CAG and/or exercise electrocardiography.Data on exposure to ETS,defined as exposure from cigarettes smoking husband or co-workers or both for at least 5 years,was obtained through standardized interviews.Standard laboratory methods were used and the lipid measurements were under US CDC quality control programs.ResultsIn the subjects defined by CAG,the levels of high density lipoprotein cholesterol (HDL-C), HDL2-C,apolipoprotein (apo) A1 among passive smokers appeared lower than those in non-passive smokers,but the low density lipoprotein cholesterol (LDL-C),apoB,apoB/A1,fibrinogen,plasma and whole blood viscosity were higher than that in non-passive smokers.There were positive associations of the numbers of coronary arteriosclerosis with the levels of blood lipids,fibrinogen and viscosity.In the non-CHD controls,81 subjects were not exposed and 127 were exposed to ETS.The P values of t-test for the adjusted (for age,body mass index,present diseases history) means between two groups were listed below: 0.06 (total cholesterol),0.30 (triglyceride),0.004 (HDL-C),0.001(HDL2-C),0.001 (apoA1), 0.009 (apoB),0.001 (apoB/apoAl),0.001 (fibrinogen),0.001(plasma viscosity),0.001 and 0.004 [two measures (5.75/s and 230/s) of whole blood viscosity].The correlation coefficients between cumulative exposure of passive smoking and HDL-C,HDL2-C,apoA1,apoB,apoB/apoA1,fibrinogen,plasma viscosity,and two measures of whole blood viscosity were -0.25,-0.27,-0.30,0.24,0.31,0.32, 0.43,0.51 and 0.36 (all P0.01),respectively.ConclusionPassive smoking could affect blood lipid metabolism,fibrinogen and viscosity in the never smoking women which might contribute to the causation of coronary heart disease. |
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