文章摘要
姚能云,徐平.博尔纳病毒感染的研究进展[J].中华流行病学杂志,2008,29(2):195-197
博尔纳病毒感染的研究进展
Progress on the study of Borna disease virus infection
收稿日期:2007-07-26  出版日期:2014-09-18
DOI:
中文关键词: 博尔纳病毒;感染
英文关键词: Borna diwasP virus; Infection
基金项目:贵州省科技基金及贵州省省长基金资助项目(2055)
作者单位E-mail
姚能云 遵义医学院附属医院神经内科, 563003 xuping527@sohu.com 
徐平 遵义医学院附属医院神经内科, 563003  
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中文摘要:
      博尔纳病(Borna disease,BD)最早见于19世纪的德国,是一种在战马中流行的伴有神经精神症状的脑膜脑炎,致死率较高,这种疾病首次在德国萨克森州博尔纳镇暴发,后以该镇名字来命名.
英文摘要:
      Objective To identify the mortality-related factors in patients undergoing maintenance hemodialysis.Methods One hundred and seven long-term hemodialysis patients having suffered from chronic glomerulonephritis and received hemodialysis treatment in the hemodialysis center of the Friendship Hospital during February 1990 to February 2002 were selected to take part in a retrospective study. Survival analysis was done using Life Tables study. Cox regression analysis was used to find factors related to risk. Patients were divided into two groups according to the clinical value of the factors which showed statistical significance in Cox regression analysis. Survive rates were compared between two groups on Gehan test.Results Among the 107 patients, 22 died (15.3%)and 85 survived (84.7%)during the follow-up period. Cumulative survival rates of 5 years and 10 years were 79.91% and 64.36% respectively. Prognostic factors would include age (P 0.001), blood urea nitrogen (BUN, P=0.004), serum creatinine (SCr, P=0.001), value of plasma calcium multiplied by plasma phosphate (P=0.019), and KT/V (P=0.001), which were all tested during the third dialysis month. The Hazard Ratios (HR) were 1.107 (95% Confidence Interval,95% CI : 1.049- 1.168), 0.951(95% CI : 0.918- 0.984), 0.727(95% CI : 0.599- 0.883), 1.025(95% CI : 1.004- 1.046), and 0.013(95% CI : 0.001- 0.161), respectively. The survival rates between two groups were significant different (age≥60 years group vs 60 years group P=0.000 6, BUN≥ 28.6 mmol/L vs 28.6 mmol/L group P=0.041 5, SCr≥884 μmol/L vs 884 μmol/L group P=0.014 6, value of plasma calcium multiplied by plasma phosphate ≥40 vs 40 group P=0.046 4, KT/V≥ 1.30 vs 1.30 group P=0.021 5).Conclusions The mortality related prognostic factors of maintained hemodialysis patients seemed to include age, BUN, SCr, value of plasma calcium multiplied by plasma phosphate, and KT/V, which were all tested during the third dialysis month. Among them, age and the value of plasma calcium multiplied by plasma phosphate were risk factors of death, while the others were protective factors.
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