安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响

吴静; 胡东; 朱钰; 张荣波

文章摘要

吴静,胡东,朱钰,张荣波.安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响[J].中华流行病学杂志,2008,29(3):245-247

安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响

The effect of rural exposure on allergic asthma in Anhui province

收稿日期:2007-08-17 出版日期:2014-09-15

DOI：

中文关键词: 哮喘过敏暴露儿童

英文关键词: Asthma Allergy Exposure Children

基金项目:

作者	单位	E-mail
吴静	安徽理工大学医学院病原生物学及免疫学教研室 232007 淮南
胡东	安徽理工大学医学院病原生物学及免疫学教研室 232007 淮南
朱钰	淮南新华医疗集团新华医院检验中心
张荣波	安徽理工大学医学院病原生物学及免疫学教研室 232007 淮南	lory41@126.com

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中文摘要:

目的研究暴露于农村生活环境对预防儿童哮喘及致敏的保护作用.方法向2986名在校儿童父母发放哮喘标准调查表,采用放射性变应原荧光酶免疫吸附实验(RAST-FEIA)检测儿童血清中特异性IgE(sIgE)含量.结果与在城镇生活的儿童相比,暴露于农村生活环境儿童的过敏性哮喘与非过敏性哮喘、过敏性哮鸣及特应性哮呜危险度显著性降低(OR=0.45,95%CI:0.13～0.96:OR=0.41,95%CI:0.15～0.95;OR=0.32,95% CI:0.11～0.62;OR=0.44,95% CI:0.13～0.91).1周岁内暴露与农村生活环境的儿童过敏性哮喘及特应性致敏危险度较低(OR=0.23,95% CI:0.04～0.91;OR=0.32,95%CI:0.17～0.78);若暴露持续至6周岁,过敏性哮喘及特应性致敏危险度更低(OR=0.21,95%CI:0.03～0.87;OR=0.31,95%CI:0.15～0.78).结论 暴露于农村环境对预防儿童过敏性哮喘及致敏的发生可能有保护作用,持续的暴露能加强此作用.

英文摘要:

Objective To establish the evidence of exposure to rural areas would reduce the risk of atopic asthma and sensitization. Methods A cross-sectional survey was carried out in 2986 school-age children and their parents completed standardized questionnaires on atopic asthma and sensitization, wheezing. A radioallergosorbent technique-fluorescence enzyme immunoassay (RAST-FEIA) was used to measure the level of specific IgE in serum. Results The risks of atopic and non-atopic asthma(OR= 0.45,95 % C1:0.13-0.96 and OR二0. 41, 95 % CI : 0. 1 S-0. 95 ), atopic sensitization and wheezing(OR= 0.32,95 % CI:o. tl-a.6z;OR=0.44,95 % C1:0.13一0.91)were lower in subjects living in village area compared with those living in towns. The risks of atopic asthma and sensitization were lower in subjects exposed to stables in first year(OR=0.23,95 % CI:0.04-0.91 and OR=0.32,9596 C1:0.77-0.78) and were lowest in those exposed continually until the age of 6(OR=0.21，95 0.6 CI : 0. 03-0. 87 and OR= 0. 31, 95 % CI :0. 1 S-0. 78 ) compared with those non-exposed in the first 6 years. Conclusion Exposure to rural environment might have a protective effect on children against atopic asthma and sensitization while continual exposure could strengthen the effects.

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