文章摘要
张奕,胡永华,曹卫华,秦雪英,任涛,陶秋山,吴涛,武轶群,詹思延,李立明."降压0号"治疗原发性高血压长期疗效和安全性评价[J].中华流行病学杂志,2008,29(3):286-289
"降压0号"治疗原发性高血压长期疗效和安全性评价
Study on the Iong-term efficacy and safety of medicine named 'Beijing Hypertensive No.0'in patients with primary hypertension
收稿日期:2007-12-06  出版日期:2014-09-15
DOI:
中文关键词: 高血压,原发性;降压0号;长期疗效;安全性
英文关键词: Primary hypertension;Beijing Hypertensive No.0;Long-term efficacy; Safety
基金项目:国家"十五"科技攻关资助项目(2001BAF03802)
作者单位E-mail
张奕 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
胡永华 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083 yhhu@bjmu.edu.cn 
曹卫华 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
秦雪英 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
任涛 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
陶秋山 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
吴涛 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
武轶群 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
詹思延 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
李立明 北京大学医学部公共卫生学院流行病与统计学系, 教育部流行病学重点实验室 100083  
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中文摘要:
      目的 系统评价长期服用"降压0号"治疗原发性高血压的降压效果和安全性.方法 采用以社区为基础的实验研究方法,将确诊的原发性高血压患者随机分至"降压0号"治疗组(0号组)或常规治疗组(常规组)治疗3年,比较两组的降压效果和观察不良反应.结果 两组共计1799人完成3年随访.与治疗前相比,0号组与常规组的收缩压分别下降13 mm Hg(1 mm Hg=0.133 kPa)和7 mm Hg,舒张压分别下降8 mm Hg和4 mm Hg,0号组的血压下降幅度大于常规组.治疗3年后,0号组和常规组的血压达标率分别为90.0%和79.5%,均较基线有显著提高.3年间0号组共有33人报告出现不良反应,占随访人数的2.6%.常见的不良反应有头晕、头痛、心悸、乏力等.服用"降压0号"1年后出现TG升高、血钾升高、血钠升高,也出现TC下降、HDL-C升高、LDL-C下降等变化,且这些指标的变化均具有统计学意义.结论 社区人群的轻中度原发性高血压患者应用"降压0号"治疗与常规治疗相比,具有更方便、有效且安全的特点.
英文摘要:
      Objective To assess the antihypertensive effect and safety on medicine named‘Beijing Hypertensive No. 0’in a three-year treatment of primary hypertension. Methods A community-based intervention study was conducted. "The antihypertensive effects and adverse events were observed. Results 4000 patients with primary hypertension were randomly divided into two groups with 1529 patients treated with `Beijing Hypertensive No.O’and 976 patients treated with other antihypertensive drugs,among which 946 and 853 patients in the two groups completed the three-year study. After treatment, the systolic blood pressure decreased 13 mm Hg and 7 mm Hg while diastolic blood pressure decreased 8 mm Hg and 4 mm Hg in the’No. O' group and controlled group respectively. After three years of treatment,90.0% and 79.596 in the `No.O'group and in the control group had reached the BP `fulfillment criteria',which were much higher than the baseline data. Side effects occurred in 33/1274 (2.fi0.6)cases during three years' treatment with most commonly seen as dizziness, headache, palpitation and weakness. No serious adverse reactions occurred. There were some positive effects after treated by‘No. 0’,including 0. 13 mmol/L decrease of TC,0.70 mmol/L decrease of LDL-C and an average 0. 12 mmol/L increase of HDL-C. All of these changes were statistically significant. There were also opposite effects as 0.13 mmol/L increase of TG, 0. 24 mmolJL increase of K',and 0. 88 mmol/L increase of Na' on average, which were also statistically significant. Conclusion Compared with the conventional treatment, this treatment of 'Beijing Hypertensive No.O' was more convenient,safe and effective in treating mild to moderate primary hvnertension in the community.
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