| 柯跃斌,程锦泉,帅志红,张仁利,江高峰,谭春荣,张遵真.深圳市新疆哈萨克族移民DNA氧化损伤的 分子流行病学研究[J].中华流行病学杂志,2008,29(7):683-684 |
| 深圳市新疆哈萨克族移民DNA氧化损伤的 分子流行病学研究 |
| Molecular epidemiological study on oxidative DNA damage among Hasake ethnic migrants in Shenzhen |
| 收稿日期:2007-09-29 出版日期:2014-09-15 |
| DOI： |
| 中文关键词: 移民 生活方式 彗星试验 8-羟基脱氧鸟苷 哈萨克族 |
| 英文关键词: Migration Life style Comet assay 8-hydroxy-2'-deoxyguanosine Hasake ethnic |
| 基金项目:深圳市科技局重点资助项目(200601020) |
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| 中文摘要: |
| 目的 研究来深圳市不同年份的新疆哈萨克族居民的DNA氧化损伤作用,探讨移民对DNA氧化损伤的影响。方法 选取60名来深圳市的新疆哈萨克族居民,按移民不同时间分为3组(每组20 人),调查其移民后主要生活方式的变化情况,采静脉血做彗星试验,收集24h尿测定8-羟基脱氧鸟苷(8-OH-dG)o结果彗星试验显示,来深圳市>3年组DNA损伤程度比<1年组均显著降低(P<0.05);移民1~3 年组的8-OH-.dG水平低于<1年组(P<0.05),移民>3年组的8-OH-dG水平明显低于<1年组(P<0.01)。 结论移民的相关生活方式变化可能具有降低哈萨克族居民的DNA氧化损伤的作用。 |
| 英文摘要: |
| Objective To explore the relationship of migration and oxidative DNA damage by comparative study of oxidative DNA damage effects on people with different years of migration among Xinjiang Hasake ethnecity in Shenzhen. Methods Sixty Hasake residents in Shenzhen were selected, and were divided into threegroups (n = 20) according to the years of migration. Major changes of their life style were investigated. 8-hydroxy- 2 ’-deoxyguanosine (8-OH-dG) levels in urine were analyzed, and comet assay of peripheral blood lymphocytes conducted. Results When comparing with thegroup having a shorter than 1 year of stay, a significant decrease of oliveive tail moment and tail/head length in comet assay in the >3 yearsgroup (P<0.05) was observed 8-OH-dG level decreased significantly in 1-3 yearsgroup (P<0.05) and >3 yearsgroup (P< 0.01). Conclusion Our results suggested that life style changes which related to migration might reduce DNA damage in Hasake nationalities. |
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