文章摘要
郑明寰,张建中.A组链球菌基因分型方法最新进展及应用[J].中华流行病学杂志,2008,29(8):839-840
A组链球菌基因分型方法最新进展及应用
A review on the advancement and application of group A Streptococcus genotyping
投稿时间:2007-11-22  
DOI:
中文关键词: A组链球菌;酿脓链球菌;基因分型
英文关键词: Group A Streptococcus;Streptococcus pyogenes;Genotyping
基金项目:
作者单位
郑明寰 中国疾病预防控制中心传染病预防控制所,北京,102206 
张建中 中国疾病预防控制中心传染病预防控制所,北京,102206 
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中文摘要:
      A组链球菌(group A Streptococcus,GAS)或酿脓链球菌(Streptococcus pyogenes)能引起多种疾病,包括猩红热、毒素休克样综合征、风湿热、咽炎及急性肾小球肾炎等。随着抗生素的广泛使用,在发达国家和地区GAS引起的重症感染其发病率曾明显下降,但20世纪80年代中后期,欧美各国也包括发展中国家相继报道风湿热的局部暴发以及侵袭性感染的发病率显著上升,使得GAS感染再次受到高度重视。
英文摘要:
      Objective Recently studies showed infections of Chlamydia pneumoniae (Cp), Helicobacter pylori (Hp) and cytomegalovirus (CMV) played roles in the development of atherosclerosis. The aim of this study was to study relationship between infection of Cp, Hp and CMV, systemic inflammatiom and coronary artery disease (CAD).Methods Fourty-five patients with at least one coronary artery stenosis 50% and 33 control subjects with negative coronary angiography were recuited for this case-control study from May 2000 to October 2001. Antibodies against Cp, Hp and CMV were measured and serum C-reactive protein (CRP) levels determined for each case. CRP level 0.8 mg/dl was defined at elevated CRP level.Results The prevalence of Cp IgG, Hp IgG or Hp IgA antibody was associated with CAD (P=0.017, P 0.001, P=0.009). After adjustment for age, gender, smoking, hypertension, hyperlipidemia and diabetes, the association was still seen. Mean CRP value was significantly higher in patients with CAD, compared to those without CAD (P 0.001). Multivariate analysis showed statistical significance (P=0.03). Elevated levels of CRP were found to be an important parameter for CAD (P=0.032). The prevalence of Cp IgG antibody, Hp IgG and CMV IgG antibody all showed no association with elevated levels of CRP (P=0.391, P=0.253, P=0.724). The ratio of elevated levels of serum basic CRP in the group with IgG antibodies to 3 pathogens was 32.1% while in the group with IgG antibodies to ≤2 pathogens it was 14.9%. But with no significante difference between the two (P=0.078).Conclusions Two chronic infections, Cp and Hp, might increase the risk of CAD. There was no association of CMV infection with CAD. C-reactive protein was an independent parameter of CAD, but the increased systemic inflammation in CAD did not seem to be related to aforesaid infection.
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