| 梁涛,刘恩武,钟华,王兵,申莉梅,乌正赉.贵州省美沙酮维持治疗受治者保持治疗状况及其影响因素[J].中华流行病学杂志,2009,30(2):131-135 |
| 贵州省美沙酮维持治疗受治者保持治疗状况及其影响因素 |
| Factors influencing the rate oil retention to methadone maintenance treatment program among heroin addicts in Guizhou,China |
| 收稿日期:2008-06-30 出版日期:2014-09-18 |
| DOI： |
| 中文关键词: 成瘾，海洛因 美沙酮维持治疗 影响因素 |
| 英文关键词: Addiction heroin Methadone maintenance treatment Influencing factors |
| 基金项目:美国中华医学基金会资助项目(CMB04-797) |
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| 中文摘要: |
| 了解美沙酮维持治疗(MMT)的受治者保持治疗率及其影响因素。方法采用队列研究设计，于2006年6-10月在贵州省8家MMT门诊选择1003名自愿参加调查、新进入MMT项海洛因成瘾者，以面对面访谈方式对影响MMT受治者保持治疗的因素进行问卷调查，并随访其保持治疗的情况至2007年6月。用Kaplan。Meier方法计算保持治疗率，Cox比例风险回归分析影响受治者保持治疗的因素。结果对MMT受治者的随访共持续14个月，受治者平均保持治疗时间为10个月。 |
| 英文摘要: |
| understand the situation of client-retention to methadone maintenance treatment(MMT)program and related factors.Methods A Cohon study was adopted.In toml,1003 heroin addicts who were treated at 8 local MMT clinics with less than one month period.were recruited under nominal informed consent from Guizhou province.southwest part of China.during June to October 2006.Face-to-face interview and questionnaire administered to collect relevant information from the clients who were also followed nntil June 2007 to understand the situation on retention.Data were analyzed with Kaplan-Meier method to estimate the retention rate at different time spans while factors related to retention were analyzed with Cox proportional hazard regression model.Results All the clients were followed-up for 14 months,with an average retention of ten months.The retention rates of the clients were 68.8%and 57.4%at 6th-month and 12th-month of the treatment program.estimated by Kaplan-Meier method.Results of Cox regression analysis showed that factors influencing retention rate on MMT among the clients,including their awareness on MMT,dailv dose of methadone intake,and difierent MMT clinics which they were attached to.Risk influencing the withdrawal from MMT had a 20%decrease along with the increase when the daily dose of methadone intake reached 25 mg,with a hazard ratio of 0.80(P＜0.01).If the clients were aware that methadone was a life-time treatment when they began the MMT program.the risk for withdrawal would be lower than those who were not and the hazard ratio became 0.66(P＜0.05).Conclusion Our data showed that about half of the clients who were at the MMT program would still stick to it after 12-months.suggesting that the retention rate was not satisfactory and need to be improved.Factors as the MMT clinics themselves that the clients visited,(Laily methadone dosage they took,and the awareness on MMT etc.were important predictors to the rate of retention on MMT program. |
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