| 宋建根,张格祥,刘旭东,马恩和,马剑华,王玉.甘肃省会宁地区403名儿童体格发育状况分析[J].中华流行病学杂志,2009,30(2):143 |
| 甘肃省会宁地区403名儿童体格发育状况分析 |
| Effectiveness of an immunization campaign with group A and C meningococcal polysaccharide vaccine in controlling an outbreak of group C meningococcal disease |
| 收稿日期:2008-06-06 出版日期:2014-09-18 |
| DOI：10.3321/j.issn:0254-6450.2008.06.009 |
| 中文关键词: 流行性脑脊髓膜炎|疫苗|应急接种|保护效果 |
| 英文关键词: Meningococcal meningitis|Vaccine|Vaccination campaign|Efficacy |
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| 中文摘要: |
| 对象与方法：调查对象为会宁县志愿者，1～5岁儿童403人，采用自行设计问卷收集儿童基本信息，同时对儿童身高、体重、头围、胸围进行测量(由抚养人陪同完成)，最后由专人核查回收问卷。 |
| 英文摘要: |
| Objective To assess the safety, immunogenicity and efficacy of group A and C meningococcal polysaccharide vaccine (A/C MPV) in response to an outbreak of group C meningococcal disease. Methods A vaccination campaign with A/C MPV was prompted 6 weeks after the use of group A MPV in Laibin city, Guangxi, where an outbreak of group C meningococcal meningitis occurred in 2002.Vaccinees were observed for local and systemic reactions after the vaccination and followed up for the meningococcal disease for 5 years. Blood samples were collected from 71 people in the epidemic and 43 in the non-epidemic areas before and 1 month after the vaccination and examined by ELISA to detect IgG antibodies to group A and C polysaccharides. Results The vaccination coverage was 97%. No significant adverse reactions were observed. The positive rates of group C antibodies after vaccination was between 97.67% and 100% among the populations in the epidemic and non-epidemic areas, as well as among those negative and positive for group C antibodies prior to the vaccination.The geometric mean anti-C concentrations ranged 30.81 μg/ml to 37.44 μg/ml, showing no significant difference between groups. The incidence rate of meningococcal disease in students with timely immunization (218.58/100 000) dropped by 69.02% , when compared to that in those with delayed immunization (705.72/100 000). No clinical cases were identified during the follow-up period of 15 760 person-years. Conclusion The vaccination campaign with the Chinese group A/C MPV seemed successful in controlling the group C meningococcal outbreak.The vaccine was shown to be safe even administered after the group A vaccine only 6 weeks apart. It could induce high levels of antibodies in vulnerable population and significantly increase antibody levels in seropositive individuals, thus providing a protection of at least 5 years. |
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