| 亓文婷,孙建东,徐爱强,张丽,李仁鹏,马吉祥,郭晓雷,樊庆莹,杨赫.山东省乙型肝炎病毒感染所致相关疾病的疾病负担研究[J].中华流行病学杂志,2009,30(7):679-683 |
| 山东省乙型肝炎病毒感染所致相关疾病的疾病负担研究 |
| Estimation on disease burden related to hepatitis B virus infection in Shandong province of China |
| 收稿日期:2008-11-27 出版日期:2014-10-16 |
| DOI：10.3760/cma.j.issn.0254-6450.2009.07.008 |
| 中文关键词: 乙型肝炎病毒 疾病负担 伤残调整寿命年 |
| 英文关键词: Hepatitis B virus Burden ofdisease Disability-adjusted life years |
| 基金项目:山东省医药卫生科技项目 |
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| 中文摘要: |
| 目的 应用伤残调整寿命年(DALYs)对山东省乙型肝炎(乙肝)、肝硬化和肝癌的疾病负担进行评价并计算HBV感染所致的总疾病负担。方法 以2004--2005年山东省第i次死因调查中乙肝、肝硬化和肝癌的死亡资料, 2005年乙肝发病资料和2007年恶性肿瘤患病调查中的肝癌患病资料与残疾权重资料为基础, 利用全球疾病负担研究方法 分别计算三类肝病的寿命损失年(YLLs)、健康寿命损失年(YLDs)和DALYs, 并估计由HBV所致的总疾病负担。结果 2005年山东省因乙肝损失211 616个DALYs(其中YLLs为39 377, YLDs为172 239), 因肝硬化损失16 783个DALYs(其中YLLs为13 497, YLDs为3286), 因HBV感染所致肝癌损失247 795个DALYs(其中YLLs为240 236, YLDs为7559);男性疾病负担分别是女性的2.19、2.36和3.16倍。乙肝疾病负担中以残疾所致的YLDs为主(81.39％), 肝硬化和肝癌疾病负担均以早死所致的YLLs为主, 分别占80.42％和96.95％。每例乙肝、肝硬化和肝癌所致的DALY损失分别为4.8、13.73和11.1l。结论 乙肝、肝硬化和肝癌对山东省人群造成沉重的疾病负担;控制HBV感染具有巨大的社会和经济效益。 |
| 英文摘要: |
| Objective To comprehensively measure the burden of hepatitis B, Iiver cirrhosis and liver cancer in Shahdong province。using disability.adjusted lire years(DALYs)to estimate the disease burden attribute to hepatitis B virus(HBV)infection.Methotis Based on the mortality data of hepatitis B.1iver cirrhosis and Iiver cancel"derived from the tIlird National Sampling Retrospective Survey for Causes of Death during 2004 and 2005.the incidence data of hepatitis B and the prevalence and the disability weights of liver cancer gained from the Shandong Cancer Prevalence Sampling Survey in 2007, we calculated the years of Iife lost(YLLs), years lived with disability(YLDs)and DALYS of three diseases foilowing the procedures developed for the global burden of disease(GBD)study to ensure the comparability.Results The total burden for hepatitis B.1iver cirrhosis and Iiver cancel"were 21l 616 (39 377 YLLs and 172 239 YLDs), 16 783(13 497 YLLs and 3286 YLDs)and 247 795(240 236 YLLs and 7559 YLDs)DALYs in 2005 respectively, and men were 2.19, 2.36 and 3.16 times as that for women。respectively in Shandong province.The burden for hepatitis B Was mainly because of disability (8 1.39%).However, most burden on liver cirrhosis and liver cancer were due to premature death (80.42%and 96.95%).The burden of each patient related to hepatitis B liver cirrhosis and Iiver cancer were 4.8.13.73 and 11.1 l respectively.Conclusion Hepatitis B.1iver cirrhosis and liver cancer caused considerable burden to the people living in Shandong province, indicating that the control of hepatitis B virus infection would bring huge potential benefits. |
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