钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析

张汝阳; 柏建岭; 易洪刚; 赵杨; 林玉娣; 张铁梅; 陈峰

文章摘要

张汝阳,柏建岭,易洪刚,赵杨,林玉娣,张铁梅,陈峰.钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析[J].中华流行病学杂志,2009,30(8):850-856

钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析

Association between calpain-10 gene polymorphism and risk of type 2 diabetes mellitus:a Meta analysis

收稿日期:2009-03-09 出版日期:2014-09-12

DOI：

中文关键词: 糖尿病,2型钙蛋白酶10 种族基因多态性分层Meta分析

英文关键词: Diabetes mellitus,type 2 Calpain-10 Race Gene polymorphism Stratified Meta analysis

基金项目:国家"十一五"科技支撑项目(2006BAI02B08)

作者	单位	E-mail
张汝阳	南京医科大学公共卫生学院流行病与卫生统计学系, 210029
柏建岭	南京医科大学公共卫生学院流行病与卫生统计学系, 210029
易洪刚	南京医科大学公共卫生学院流行病与卫生统计学系, 210029
赵杨	南京医科大学公共卫生学院流行病与卫生统计学系, 210029
林玉娣	无锡市疾病预防控制中心
张铁梅	卫生部北京医院卫生部北京老年医学研究所
陈峰	南京医科大学公共卫生学院流行病与卫生统计学系, 210029	fengchen@njmu.edu.cn

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中文摘要:

目的探讨钙蛋白酶10(CAPN10)基因SNP43、SNP44位点及主要单倍型、单倍型组合与2型糖尿病(T2DM)的关联性.方法根据系统评价的原理和规范,检索PubMed及中文期刊数据库,纳入CAPN10基因与T2DM的病例对照研究.根据种族,采用分层Meta分析评估CAPN10基因多态性与T2DM的关联性.同时评估发表偏倚.结果各种族与T2DM有关联的基因多态性分别是:蒙古人种,SNP43位点G等位基因OR=1.368(95%CI:1.155～1.620),G/G基因型OR=1.437(95%CI:1.186～1.741),111/221单倍型组合OR=2.762(95%CI:1.287～5.927);高加索人种,SNP44位点C等位基因OR=1.144(95%C1:1.023～1.278),111/111单倍型组合OR=1.291(95%CI:1.050～1.586);混血人种,SNP44位点C等位基因OR=1.653(95%CI:1.025～2.665).结论 SNP43位点G等位基因、G/G基因型、111/221单倍型组合是蒙古人种的危险因素;SNP44位点C等位基因、111/111单倍型组合是高加索人种的危险因素;SNP44位点C等位基因是混血人种的危险因素.

英文摘要:

Objective The purpose of this study was to approach the relation of SNP43,SNP44 locus, main haplotypes and haplotype combinations with type 2 diabetes mellitus(T2DM).Methods According to the theory and principles of systematic review,data from case-control studies regarding the association between calpain-10(CAPN10) gene and T2DM were derived through electronic search of PubMed and Chinese journals databases.To gain a more precise estimation of the relationship,a stratified Meta-analysis with four subgroups was pertbrmed according to the races.Publication bias Was also assessed.Results The association with T2DM in different races was evaluated.In Mongoloid race,SNP43-G allele,G/G genotype and 111/221 haplotype combination showed notable association with T2DM with ORs (95%CI) as 1.368(1.155-1.620),1.437(1.186-1.741) and 2.762 (1.287-5.927) respectively.In Caucasoid race,SNP44-C allele,111/111 hapotype combination showed strong relationship with T2DM with Ors(95%CI) as 1.144(1.023-1.278),1.291(1.050-1.586) respectively.In Hybrid race,only one positive finding Was obtained which Was SNP44-C allele with OR(95%CI)as 1.653(1.025-2.665).Conclusion SNP43-G allele,G/G genotype,111/221 were risk factors to Mongoloid race.And SNP-C allele,111/111 haplotype combination were risk factors to Caucasoid race,and SNP44-C allele to Hybrid race.

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