文章摘要
蔡旭玲,郜艳晖,余卓文,吴兆权,周卫平,杨翌,许雅,宋韶芳,陈思东.HBV、HCV感染和XPC基因Ala499Val、Lys939Gln与肝癌关系的1:1匹配病例对照研究[J].中华流行病学杂志,2009,30(9):942-945
HBV、HCV感染和XPC基因Ala499Val、Lys939Gln与肝癌关系的1:1匹配病例对照研究
A 1:1 matehed case.eontrol study on the interaction between HBV。HCV infection and DNArepair gene XPC Ala499Val,Lys939GIn for primary hepatocellular carcinoma
投稿时间:2009-03-07  修订日期:2007-09-20
DOI:
中文关键词: 发性肝癌;XPC基因多态性;乙型肝炎病毒感染;丙型肝炎病毒感染;交互作用
英文关键词: mary hepatocellular carcinoma;xPc gene polymorphisms;Hepatitis B virus infection;Hepatitis Cvirus infection;Interaction
基金项目:国家自然科学基金青年基金(30500421)
作者单位E-mail
蔡旭玲 广东药学院公共卫生学院, 广州 510310 chensidong@tom.com 
郜艳晖 广东药学院公共卫生学院, 广州 510310  
余卓文 佛山市顺德区慢性病防治中心  
吴兆权 佛山市顺德区慢性病防治中心  
周卫平 广东药学院公共卫生学院, 广州 510310  
杨翌 广东药学院公共卫生学院, 广州 510310  
许雅 广东药学院公共卫生学院, 广州 510310  
宋韶芳 广东药学院公共卫生学院, 广州 510310  
陈思东 广东药学院公共卫生学院, 广州 510310 Med_bp@zju.edu.cn 
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中文摘要:
      目的探讨环境因素HBV、HCV感染与DNA修复基凶XPC第8外显子Ala499Val、第15外显子Lys939Gln交互作用在原发性肝癌(肝癌)发生中的作用。方法在广东省顺德地区采用1:1匹配的病例对照研究,PCR技术检测Ala499Val、Lys939Gln基因型,条件logistic回归分析环境与基因单独作用和交互作用对肝癌的影响。结果HBsAg阳性者中,无携带Ala499Val突变型基因者和至少携带一个突变型基因者的OR值分别为3.768(95%CI:1.137~12.485)和3.667(95%C1:1.122-11.981);无携带Lys939Gln突变型基因者和至少携带一个突变型基因与肝癌关联的OR值分别为6.778(95%CI:2.025。22.688)和3.152(95%CI:1.062~9.351)。HCV感染者中,无携带Ala499Val突变型基因和至少携带一个突变型基因的OR值为2.955(95%C1:0.587~14.869)和1.085(95%CI:0.307-3.839);携带至少一个突变型基因和无携带Lys939Gln突变型基因相比,OR值由4.197(95%C1:0.870~20.243)降低为0.887(95%CI:0.228~3.448)。但基于相乘模型的基因和环境交互作用均未达到统计学意义。结论携带Ala499Val突变型基因有降低HCV感染者的肝癌发病风险的趋势;而携带Lys939Gln突变型基因对HBV感染者和HCV感染者的肝癌发病风险都有降低的趋势,需要加大样本量进一步研究。
英文摘要:
      Objective To evaluate the interaction between environmental factors,HBV/HCV infections and DNA repair gene XPC exon 8 Ala499Val。exon l 5 Lys939Gln on relatedrisks to primary hepatocellular cal'cinoma(PHC).Methods A l:l matched case-control study was conducted in Shunde city,Guangdong province.The genotypes of Ala499Val and Lys939Gln were detected by polymerase ehain reaction restrictive fragment length polymorphism(PCR-RFLP)analysis.and gene.environment interactions were analyzed by conditionallogistic regression.ResultsAmong people infected by HBVwith non-or at least one mutant gene of Ala499Vm carriers.the risk of PHC significantly increased,With ORs as 3.768(95%CI:1.137-12.485)and 3.667(95%CI:1.122-11.981)respectively.With non.or at least one mutant gene of Lys939Gin.the risk was increasingwith 0Rs as 6.778(95%CI:2.025-22.688)and 3.152(95%CI.062-9.351)respectively.In those with HCV infection,non.or at 1east one mutant gene of Ala499Val might increase the risk with f)Rs as 2.955 (95%Ci:0.587-14.869),1.085(95%CI:0.307-3.839)respectively.However,when compared to theones with no mutant gene of Lys939Gin among the same research subjects.thoge carrying at leastone genemaydecreasethe risk.with OR lowered from4.197(95%Ci:0.870-20.243)to 0.887(95%CI:0.228-3.448).But the interactions between船V infection.HCV infection andⅫC genes were notstatistically significant.Conclusion Among people infected by HCV.the mutant gene ofMa499Ⅷhad the tendency to lower the risk of P’HC,and the mutant gene of Lys939GIn also appeared the same in the population with either HBV infecfion or HCV infection in Shunde.Guangdong.Another study with large samples should be performedto analyze the interactions among environments-genes.
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