文章摘要
廖佩花,秦江梅,曾同霞,李锋,蔡金凤,何玲.HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1:2病例对照研究[J].中华流行病学杂志,2009,30(9):951-954
HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1:2病例对照研究
A 1:2 matehed case-controI study on the interaction of HPVl6E6 and HLA-DR9 allele toesophageal cancer in Kazakh ethnicity,Xinjiang
投稿时间:2009-02-27  修订日期:2007-08-17
DOI:
中文关键词: 食管癌;人乳头瘤病毒;人类白细胞抗原;病例对照研究;哈萨克族
英文关键词: Esophageal callcer;Human papillomavirus;Human leukocyte antigen;Casecontrol study;Kazakh
基金项目:国家自然科学基金(30660161);国家“973”计划f搿期研究专项(2007CB516804)
作者单位E-mail
廖佩花 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002  
秦江梅 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002 qinjiangmei@yahoo.com.cn 
曾同霞 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002  
李锋 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002  
蔡金凤 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002  
何玲 石河子大学医学院预防医学系新疆地方与民族高发病省部共建教育部重点实验室 832002  
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中文摘要:
      目的探讨人乳头瘤病毒(HPv)16E6感染、人类白细胞抗原(阳jA).DR9免疫相关基因对新疆哈萨克族人群食管癌的影响及相互关系。方法采用1:2配比的病例对照研究方法,收集63例哈萨克族食管癌患者,按同性别、同民族、年龄相差≤5岁且居住同一地区等选取对照126例,运用序列特异性聚合酶链反应(PCR.SSP),检测HPVl6E6的感染率及HLA-DR9等位基因阳性率。交互作用采用分层分析的方法。结果HPVl6E6感染和HLA.DR9等位基因阳性均为哈萨克族食管癌的危险因素,OR值分别为2.67(95%c,:1.38~5.17)和3.83(95%c,:1.48,9.96)。在食管癌组中HLA.DR9等位基因阳性组HPVl6E6感染率为69.2%,明显高于HLA.DR9等位基因阴性组的28.O%(z2=7.57,P=O.006),OR=5.79(95%c,:1.53~21.87),对照组中,HLA.DR9等位基因阳性和阴性组的HPVl6E6感染率分别22.2%和16.2%,差异无统计学意义(X2————-O.22,P=0.643)。交互作用提示:HPVl6E6及HLA-DR9等位基因存在交互作用,其危险性高于各单独作用之和。结论HPVl6E6感染及HLA.DR9等位基凶阳性与哈萨克族人群食管癌发生密切相关,两者在食管上皮细胞恶性转化的过程中起到协同作用,共同促进食管癌的发生和发展。
英文摘要:
      objective To evaluate the role and the association between HPVl6E6 infectionand HLA.DR9 immune.associated gene to esophageal cancer(EC)in Kazakh of Xiniiang.China.Methods A l:2 matched case·control study Was conducted witll 63 cases of EC and 126 controls involved.The controls were matched by sex.nationality。area of residence and age within 5一year difference.HPVl6E6 and HLA-DR9 allele were identified by PCR.SSP.Interaction Was performed to identify risk factors.Results HPVl6E6 infection and HLA.DR9 allele positive status were the risk factors for EC.witll DR values as 2.67(95%C/:1.38-5.17)and 3.83(95%C/:1.48-9.96)respectively. The rate of HPVl 6E6 infection in individuals with HLA-DR9 allele Was different from the ones who were HLA.DR9 allele free(3(2=7.57,P=0.006),witll f)R value as 5.79(95%C7:1.53-21.87).In the controls.the rates of HPVl6E6 infection were 22.2%and 16.2%among individuals with HLA-DR9 allele atatus as positive or negative,and without statistically significant difference.Interaction analysis showed there Was all interaction of HPVl6E6 wi吐l HLA-DR9 and were higher than the sum of the two factors presented individually.Conclusion In our study.we found that the HLA.DR9 allele and HPVl6E6 infection had a function of synergy in the process of malignant transformation of esophageal epithelial cells,and iointly promoting the occurrence and development of EC.
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