廖佩花,秦江梅,曾同霞,李锋,蔡金凤,何玲.HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1:2病例对照研究[J].中华流行病学杂志,2009,30(9):951-954 |
HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1:2病例对照研究 |
A 1:2 matehed case-controI study on the interaction of HPVl6E6 and HLA-DR9 allele toesophageal cancer in Kazakh ethnicity,Xinjiang |
收稿日期:2009-02-27 出版日期:2014-09-15 |
DOI: |
中文关键词: 食管癌 人乳头瘤病毒 人类白细胞抗原 病例对照研究 哈萨克族 |
英文关键词: Esophageal callcer Human papillomavirus Human leukocyte antigen Casecontrol study Kazakh |
基金项目:国家自然科学基金(30660161);国家“973”计划f搿期研究专项(2007CB516804) |
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中文摘要: |
目的探讨人乳头瘤病毒(HPv)16E6感染、人类白细胞抗原(阳jA).DR9免疫相关基因对新疆哈萨克族人群食管癌的影响及相互关系。方法采用1:2配比的病例对照研究方法,收集63例哈萨克族食管癌患者,按同性别、同民族、年龄相差≤5岁且居住同一地区等选取对照126例,运用序列特异性聚合酶链反应(PCR.SSP),检测HPVl6E6的感染率及HLA-DR9等位基因阳性率。交互作用采用分层分析的方法。结果HPVl6E6感染和HLA.DR9等位基因阳性均为哈萨克族食管癌的危险因素,OR值分别为2.67(95%c,:1.38~5.17)和3.83(95%c,:1.48,9.96)。在食管癌组中HLA.DR9等位基因阳性组HPVl6E6感染率为69.2%,明显高于HLA.DR9等位基因阴性组的28.O%(z2=7.57,P=O.006),OR=5.79(95%c,:1.53~21.87),对照组中,HLA.DR9等位基因阳性和阴性组的HPVl6E6感染率分别22.2%和16.2%,差异无统计学意义(X2————-O.22,P=0.643)。交互作用提示:HPVl6E6及HLA-DR9等位基因存在交互作用,其危险性高于各单独作用之和。结论HPVl6E6感染及HLA.DR9等位基凶阳性与哈萨克族人群食管癌发生密切相关,两者在食管上皮细胞恶性转化的过程中起到协同作用,共同促进食管癌的发生和发展。 |
英文摘要: |
objective To evaluate the role and the association between HPVl6E6 infectionand HLA.DR9 immune.associated gene to esophageal cancer(EC)in Kazakh of Xiniiang.China.Methods A l:2 matched case·control study Was conducted witll 63 cases of EC and 126 controls involved.The controls were matched by sex.nationality。area of residence and age within 5一year difference.HPVl6E6 and HLA-DR9 allele were identified by PCR.SSP.Interaction Was performed to identify risk factors.Results HPVl6E6 infection and HLA.DR9 allele positive status were the risk factors for EC.witll DR values as 2.67(95%C/:1.38-5.17)and 3.83(95%C/:1.48-9.96)respectively. The rate of HPVl 6E6 infection in individuals with HLA-DR9 allele Was different from the ones who were HLA.DR9 allele free(3(2=7.57,P=0.006),witll f)R value as 5.79(95%C7:1.53-21.87).In the controls.the rates of HPVl6E6 infection were 22.2%and 16.2%among individuals with HLA-DR9 allele atatus as positive or negative,and without statistically significant difference.Interaction analysis showed there Was all interaction of HPVl6E6 wi吐l HLA-DR9 and were higher than the sum of the two factors presented individually.Conclusion In our study.we found that the HLA.DR9 allele and HPVl6E6 infection had a function of synergy in the process of malignant transformation of esophageal epithelial cells,and iointly promoting the occurrence and development of EC. |
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