| 张慧颖,孙玉叶,陈素芬,吕景娟,杨柳,夏薇,孙彩虹,王忆军.男性代谢综合征对青春期子代影响的家族聚集性分析[J].中华流行病学杂志,2010,31(2):126-128 |
| 男性代谢综合征对青春期子代影响的家族聚集性分析 |
| Familial aggregation of metabolic syndrome in adolescents with paternal metabolic syndrome |
| 收稿日期:2009-07-06 出版日期:2014-09-12 |
| DOI： |
| 中文关键词: 代谢综合征 家族聚集性 青春期 |
| 英文关键词: Metabolic syndrome Familial aggregation Adolescent |
| 基金项目:黑龙江省自然科学基金(D200604) |
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| 中文摘要: |
| 目的分析男性代谢综合征(MS)患者青春期子代和健康人青春期子代的MS各组分及血清超敏c反应蛋白(hs.CRP)等疾病表型的差异，探讨MS及其相关组分的家族聚集特征。方法采用遗传流行病学1:3病例对照家系设计，确定26例男性MS作为先证者(病例组)以及78名健康人作为对照组。通过体格检查和实验室检查收集两组研究对象青春期子代的疾病表型信息。测定身高、体重、腰围、臀围、血压，计算BMI、腰臀比和腰嗣身高比。实验室检测窄腹血糖、血脂四项及血清hs.CRP含量。结果MS病例组青春期子代的肥胖指标(腰围、腰围身高比、腰臀比、DBP值)及hs.CRP值均高于对照组的青春期子代(P结论病例与对照组青春期子代的疾病表型存在差异；提示MS的家族聚集性在青春期即已体现，主要表现在中心性肥胖、血压升高和炎症表达明显。 |
| 英文摘要: |
| Objetive To analyze the impact of parental Metabolic Syndrome(MS)on adolescents.and to explore the familial aggregation of MS wim its components.Methods Using a1:3 case.control familial study design to choose 26 MS male patients as proband and 78 healthy men as controls.Data regarding phenotype of their adolescence offspring were collected.Height，weight，waist circumference(WC)。blood pressure，body mass index(BMI)，waist.to-hip ratio(WHR)and waist.to.height ratio(WHtR)were measured or calculated.FPG，TC，TG，HDL-C and LDL-C were detected by automatic biochemical analyzer and hs-CRP wag detected.Results WC，WHtR，WHR，DBP and hs.CRP of those adolescents with paternal MS were significantly higher than in controls(PConclusion The phenotypes of MS were different between adolescents with or without parental MS.indicating that the familial aggregation of MS had been existed in their adolescent offspring.and mainly presented in central obesity.increased blood
pressure and inflammation. |
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