| 刘海行,赵冬,王薇,秦兰萍,刘军,孙佳艺,王淼,李岩,齐玥,刘静.血清高敏C反应蛋白水平与五年累积糖尿病发病风险的关系[J].中华流行病学杂志,2011,32(1):1-4 |
| 血清高敏C反应蛋白水平与五年累积糖尿病发病风险的关系 |
| Association between high sensitivity C-reactive protein levels in serum and the 5-year-accumulative-risk of diabetes |
| 收稿日期:2010-09-21 出版日期:2014-09-10 |
| DOI： |
| 中文关键词: 糖尿病 高敏C反应蛋白 前瞻性研究 |
| 英文关键词: Diabetes High-sensitivity C-reactive protein Prospective study |
| 基金项目:北京市自然科学基金(7082019);北京市卫生系统高层次卫生技术人才培养计划(2009-3-46);省部共建教育部心血管重塑相关疾病重点实验室(110267) |
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| 中文摘要: |
| 目的 研究高敏C反应蛋白(hs-CRP)与5年糖尿病发病风险的关系。方法 研究对象来源于“中国多省市心血管病前瞻性队列研究”中的北京大学社区队列。2002年对该队列45～74岁1541人进行心血管病危险因素调查和hs-CRP水平测定，2007年进行危险因素复查，对两次资料完整且基线无糖尿病和感染性疾病的1045人进行分析。结果 研究人群5年间糖尿病的年龄标化累积发病率为8.8%，男性为9.8%，女性为8.2%。基线hs-CRP水平四分层后显示：男女两性糖尿病的累积发病率均有随hs-CRP水平升高而逐渐增加的趋势(P<0.01)。调整基线年龄、高血压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、血糖、吸烟和腹部肥胖后，男女两性中hs-CRP≥3mg/L者发生糖尿病危险分别是hs-CRP<1 mg/L者的3.30倍(95%CI：1.25～8.73)和2.58倍(95%CI：1.06～6.29)。男女两性基线hs-CRP水平判定糖尿病是否发病的ROC曲线下面积分别为0.619(95%CI：0.536～0.701)和0.667(95%CI：0.585～0.749)。结论 基线hs-CRP水平是糖尿病发病的独立预测因素，提示慢性炎症在糖尿病发生的病理过程中发挥重要作用。 |
| 英文摘要: |
| Objective To analyze the association between hs-CRP (high-sensitivity C-reactive protein) levels in serum and the 5-year-accumulative-risk of diabetes in a general population. Methods Participants were from the cohort of Peking University residential community in the Chinese Multi-provincial Cohort Study (CMCS). Two surveys on cardiovascular risk factors and the measurements of serum hs-CRP levels were conducted in 2002 and 2007, respectively. Individuals with incomplete information and those having infectious diseases at baseline were excluded. A total of 1045 participants aged 45 to 74 years and free of diabetes at baseline were included in this analysis. Results The age-standardized 5-year accumulative incidence rate of diabetes was 8.8% (male: 9.8%, female: 8.2%) and increased significantly with the level of hs-CRP in both women and men (P<0.01). After adjustment for age, hypertension, low-density liproprotein cholesterol, and high-density liproprotein cholesterol, triglycerides, fasting glucose, smoking status and central obesity, people with hs-CRP≥3 mg/L had a 3.30 times higher risk of developing diabetes in men and 2.58 times for women when compared to those with hs-CRP<1 mg/L. The areas under the receiver operating characteristic curves of baseline hs-CRP level in predicting the incidence of diabetes were 0.619 (95%CI: 0.536-0.701) in men and 0.667 (95%CI: 0.585-0.749) in women. Conclusion Serum hs-CRP levels could predict the incidence of diabetes, indicating that inflammation might have great importance in the onset of diabetes. |
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