| 庞颜坤,李立群,丁峥嵘,彭敏,朱元清,王正有,李艳.一起缅甸输入新型麻疹病毒(d11基因型)引发暴发疫情的调查分析[J].中华流行病学杂志,2011,32(1):17-19 |
| 一起缅甸输入新型麻疹病毒(d11基因型)引发暴发疫情的调查分析 |
| Investigation on an outbreak of measles caused by new virus (d11 genotype) imported from Myanmar |
| 收稿日期:2010-08-16 出版日期:2014-09-10 |
| DOI： |
| 中文关键词: 麻疹病毒 暴发疫情 缅甸输入 |
| 英文关键词: Measles virus Outbreak Myanmar input |
| 基金项目: |
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| 中文摘要: |
| 目的 研究缅甸输入新型麻疹病毒(d11基因型)导致暴发疫情的相关因素及阻断传播的有效策略和措施。方法 应用流行病学方法进行现场暴发调查。结果 云南省孟连县4个乡镇(66%)报告麻疹15例，6月龄至5岁儿童7例，2例有麻疹疫苗(MV)免疫史；21～49岁8例，免疫史均不详。缅甸入境人员就诊14例，年龄10月龄至13岁，仅1例接种过MV。除1例缅甸病例未采到标本外，其余28例患者麻疹IgM抗体均为阳性，有6例标本检测到麻疹病毒核酸，扩增后测序为麻疹病毒d11基因型，为缅甸输入的d11基因型野病毒。MV接种率和抗体水平调查184人，接种率61.96%，麻疹IgG抗体阳性率87.50%。及时开展MV应急接种，麻疹疫情得到有效控制。结论 境外输入麻疹病例可以引发境内麻疹流行，预示云南省消除麻疹面临巨大困难和挑战；应急接种MV可以阻断传播，说明目前使用的MV对预防d11基因型麻疹病毒感染同样有效。 |
| 英文摘要: |
| Objective To study the relevant factors on an measles outbreak caused by imported new virus (d11 genotype) from Myanmar and to develop effective strategies and measures. Methods On-site investigation on the outbreak was carried out. Results There were four townships (66%) in Menglian county reported 15 cases of measles, with 7 cases aged 6 months to 5 years old, 2 cases with the history of measles vaccination (MV). Another 8 cases were 21 to 49 year-olds but their histories on immunization were unclear. 14 of the measles cases with Myanmar citizenship came to China for treatment. They were aged 10 months to 13 years old, with only one case had ever received MV vaccination. For all the 29 cases, except for one case who did not adopt the sample case of Myanmar, the remaining 28 patients were positive for measles IgM antibodies. 6 cases of measles virus RNA were detected in the amplified sequence which showed genotype d11, and was considered Myanmar imported wild virus. 184 people received the MV inoculation, with a rate of 61.96% and the serum samples showed a measles IgG antibody positive rate of 87.50%. Manner MV emergency vaccination was carried out timely in that county so the measles outbreak was effectively controlled. Conclusion Imported measles cases from foreign countries might lead to epidemic, indicating the difficulty and challenge in the elimination of measles in our province. Emergent vaccination of MV could interrupt the transmission of the disease. Our experience showed that MV was effective in the prevention of d11 genotypes measles infection in the area. |
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