| 何寒青,李倩,何奔,高雯洁,姚凤燕,蒋雪峰,沈月根,周建红,陈恩富.中学生接种甲型H1N1流感疫苗保护效果的评价[J].中华流行病学杂志,2011,32(7):661-663 |
| 中学生接种甲型H1N1流感疫苗保护效果的评价 |
| Epidemioiogieal effects of the A(H1N1)influenza vaccine immunization program on students |
| 收稿日期:2011-02-14 出版日期:2014-09-10 |
| DOI： |
| 中文关键词: 甲型H1NI流感疫苗 保护性效果 评价 |
| 英文关键词: A(H1NI)influenza vaccine Epidemiological effects Evaluation |
| 基金项目:浙江省医药卫生科技计划(2010KYA054) |
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| 中文摘要: |
| 目的了解中学生接种甲型H1NI流感疫苗的保护效果。方法采用非随机对照临床试验方法，选择8所中学14 883名学生，分甲型H1NI流感疫苗接种组6334人，对照组(未接种)8549人．随访观察一个流行周期(6个月)，比较两组流感样病例、甲型HINl流感病例、季节性流感病例的发生率。结果所有研究对象累计观察7441．75人年。接种组流感样病例发病密度为1．47／1000人年。低于对照组(22．69／1000人年)，差异无统计学意义(P>0．05)；接种组甲型HINl流感发病密度为0。低于对照组1．64／1000人年，两者率差为一1．6411000人年(95％CI：一3．04一一O．23)，差异有统计学意义(P=0．010)；接种组流感病毒核酸阳性病例发病密度为6．63／1000人年，低于对照组(7．02／1000人年)，差异无统计学意义(P>0．05)；接种组乙型流感发病密度为6．63／1000人年，高于对照组(5．38／1000人年)，差异无统计学意(P>0．05)。结论学生大规模接种甲型HINl流感疫苗能有效预防甲型HINl流感，其保护效果良好，但对于其他季节性流感可能无交叉保护作用。 |
| 英文摘要: |
| Objective To evaluate the epidemiological effects of vaccine immunization program related to A(H1 N1)influenza in the middle school students．Methods Non．randomized clinical trial was designed to assess the A(H1N1)influenza vaccine on its emcacy．14 883 students from 8 middle schools in Zhejiang province were recruited and classified into vaccinated or control groups．based on the status of immunization with A(HlNl)influenza vaccine．A11 subjects were followed up through one epidemic period(6 months)and the incidence rates of influenza．1ikeillnesses．A(H1N1)influenza．and seasonal influenza in these two groups were compared to evaluate the efficacy of the vaccine．Results There were 6334 subjects in the vaccinated group and 8549 in the control group．7441．75 person-years were followed from these two groups．The incidence rate ofA (HlNl)influenza in vaccinated group was 1．64％。per person—year．10wer than that of the control group．The rate difference(RD)was—1．64％o per person-year(95％confidence interval value from一3．04％。to一0．23％D per person—year)．and the difference was significant(P=O．010)．Theincidence rate ofinfluenza．1ike illnesses in vaccinated group was 21．47％0 per person—year。Iower than that of the control group(22．69％。per person—year)and the difference was not significant(P>0．05)．The incidence rate of B influenza in vaccinated group was 6．63‰per person-year．higher than that of control group(7．02％o per person．year)but the difference was not significant(P>0．05)．Conclusion This vaccine demonstrated a good epidemiological effect against the A(HlNl)influenza virus infection．observed through a student—immunization program．The cross．protection effect against the influenza．1ike illnesses and other seasonal influenzas was not noticed in this study． |
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