| 陈园生,李黎,崔富强,邢文革,王璐,贾志远,周脉耕,龚晓红,王富珍,郑徽,罗会明,毕胜利,汪宁,杨维中,梁晓峰.中国丙型肝炎血清流行病学研究[J].中华流行病学杂志,2011,32(9):888-891 |
| 中国丙型肝炎血清流行病学研究 |
| A sero-epidemiological study on hepatitis C in China |
| 收稿日期:2011-05-10 出版日期:2014-09-11 |
| DOI： |
| 中文关键词: 丙型肝炎 血清流行病学 |
| 英文关键词: Hepatitis C Sero-epidemiology |
| 基金项目: |
| 作者 | 单位 | E-mail | | 陈园生 | 中国疾病预防控制中心, 北京 100050 | | | 李黎 | 中国疾病预防控制中心, 北京 100050 | | | 崔富强 | 中国疾病预防控制中心, 北京 100050 | | | 邢文革 | 中国疾病预防控制中心, 北京 100050 | | | 王璐 | 中国疾病预防控制中心, 北京 100050 | | | 贾志远 | 中国疾病预防控制中心, 北京 100050 | | | 周脉耕 | 中国疾病预防控制中心, 北京 100050 | | | 龚晓红 | 中国疾病预防控制中心, 北京 100050 | | | 王富珍 | 中国疾病预防控制中心, 北京 100050 | | | 郑徽 | 中国疾病预防控制中心, 北京 100050 | | | 罗会明 | 中国疾病预防控制中心, 北京 100050 | | | 毕胜利 | 中国疾病预防控制中心, 北京 100050 | | | 汪宁 | 中国疾病预防控制中心, 北京 100050 | | | 杨维中 | 中国疾病预防控制中心, 北京 100050 | | | 梁晓峰 | 中国疾病预防控制中心, 北京 100050 | liangxf@hotmail.com |
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| 中文摘要: |
| 目的 了解中国现阶段丙型肝炎病毒(HCV)感染现状。方法利用中国疾病预防控制中心“2006年中国乙型病毒性肝炎血清流行病学调查”保留的血清，以美国Murex 3.0和Ortho 3.0抗-HCV试剂为金标准建立标准血清库，筛选中国抗-HCV检测试剂，并用Chiron HCVRIBA 3.0复核检测结果。结果 中国1～ 59岁人群抗-HCV调整流行率为0.43％(95％CI:0.33％～0.53％)，男性和女性抗-HCV流行率分别为0.46％和0.40％，城市和农村人群经调整后均为0.43％。东、中和西部地区人群抗-HCV流行率分别为0.37％（95％CI:0.21％～0.53％）、0.67％(95％CI:0.40％～0.94％)和0.31％ (95％CI:0.20％ ～ 0.42％)，3个地区人群抗-HCV流行率的差异无统计学意义；南方和北方地区人群抗-HCV流行率分别为0.29％(95％CI:0.21％～0.52％)和0.53％(95％CI:0.38％ ～ 0.64％)。结论经综合性防治，目前中国属丙型肝炎低流行区。 |
| 英文摘要: |
| Objective To better understand and measure the status of hepatitis C virus (HCV) infection, we conducted a sero-epidemiological study using the remaining blood samples and data of the nationwide survey of hepatitis B in Chinese residents which was carried out in 2006.Methods The anti-HCV reagent was screened out from the reagents by the HCV infection blood serum plate with anti-HCV positives or negatives. This plate recognized the Murex 3.0 and Ortho 3.0 reagents as gold standards. Anti-HCV in the blood samples were tested using this reagent and confirmed by Chiron HCV RIBA 3.0 reagents.Results Among the population aged 1 year to 59 year-olds, the overall prevalence rate of anti-HCV was 0.43％ (95％CI: 0.33％-0.53％ ), with the rates of anti-HCV among males and females as 0.46％ and 0.40％, respectively. The prevalence rate of anti-HCV in urban area was 0.43％,and in rural area it was 0.43％. The prevalence rate of anti-HCV in the Eastern, Middle and Western areas were 0.37％ (95％ CI: 0.21％-0.53％ ), 0.67％ (95％ CI: 0.40％-0.94％ ) and 0.31％ (95％CI: 0.20％-0.42％ ) respectively. The prevalence rates of anti-HCV for the three areas did not show significant differences, statistically. The prevalence rate of anti-HCV in the South and North areas were 0.29％(95％CI:0.21％-0.52％) and 0.53％ (95％CI:0.38％-0.64％)respectively.Conclusion Our data revealed that China was in the low prevalence area for hepatitis C infection and the results also suggested that the comprehensive measures for HCV control and prevention had been successfully achieved in the country. |
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