文章摘要
陈园生,李黎,崔富强,邢文革,王璐,贾志远,周脉耕,龚晓红,王富珍,郑徽,罗会明,毕胜利,汪宁,杨维中,梁晓峰.中国丙型肝炎血清流行病学研究[J].中华流行病学杂志,2011,32(9):888-891
中国丙型肝炎血清流行病学研究
A sero-epidemiological study on hepatitis C in China
投稿时间:2011-05-10  
DOI:
中文关键词: 丙型肝炎;血清流行病学
英文关键词: Hepatitis C;Sero-epidemiology
基金项目:
作者单位E-mail
陈园生 中国疾病预防控制中心, 北京 100050  
李黎 中国疾病预防控制中心, 北京 100050  
崔富强 中国疾病预防控制中心, 北京 100050  
邢文革 中国疾病预防控制中心, 北京 100050  
王璐 中国疾病预防控制中心, 北京 100050  
贾志远 中国疾病预防控制中心, 北京 100050  
周脉耕 中国疾病预防控制中心, 北京 100050  
龚晓红 中国疾病预防控制中心, 北京 100050  
王富珍 中国疾病预防控制中心, 北京 100050  
郑徽 中国疾病预防控制中心, 北京 100050  
罗会明 中国疾病预防控制中心, 北京 100050  
毕胜利 中国疾病预防控制中心, 北京 100050  
汪宁 中国疾病预防控制中心, 北京 100050  
杨维中 中国疾病预防控制中心, 北京 100050  
梁晓峰 中国疾病预防控制中心, 北京 100050 liangxf@hotmail.com 
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中文摘要:
      目的 了解中国现阶段丙型肝炎病毒(HCV)感染现状。方法利用中国疾病预防控制中心“2006年中国乙型病毒性肝炎血清流行病学调查”保留的血清,以美国Murex 3.0和Ortho 3.0抗-HCV试剂为金标准建立标准血清库,筛选中国抗-HCV检测试剂,并用Chiron HCVRIBA 3.0复核检测结果结果 中国1~ 59岁人群抗-HCV调整流行率为0.43%(95%CI:0.33%~0.53%),男性和女性抗-HCV流行率分别为0.46%和0.40%,城市和农村人群经调整后均为0.43%。东、中和西部地区人群抗-HCV流行率分别为0.37%(95%CI:0.21%~0.53%)、0.67%(95%CI:0.40%~0.94%)和0.31% (95%CI:0.20% ~ 0.42%),3个地区人群抗-HCV流行率的差异无统计学意义;南方和北方地区人群抗-HCV流行率分别为0.29%(95%CI:0.21%~0.52%)和0.53%(95%CI:0.38% ~ 0.64%)。结论经综合性防治,目前中国属丙型肝炎低流行区。
英文摘要:
      Objective To better understand and measure the status of hepatitis C virus (HCV) infection, we conducted a sero-epidemiological study using the remaining blood samples and data of the nationwide survey of hepatitis B in Chinese residents which was carried out in 2006.Methods The anti-HCV reagent was screened out from the reagents by the HCV infection blood serum plate with anti-HCV positives or negatives. This plate recognized the Murex 3.0 and Ortho 3.0 reagents as gold standards. Anti-HCV in the blood samples were tested using this reagent and confirmed by Chiron HCV RIBA 3.0 reagents.Results Among the population aged 1 year to 59 year-olds, the overall prevalence rate of anti-HCV was 0.43% (95%CI: 0.33%-0.53% ), with the rates of anti-HCV among males and females as 0.46% and 0.40%, respectively. The prevalence rate of anti-HCV in urban area was 0.43%,and in rural area it was 0.43%. The prevalence rate of anti-HCV in the Eastern, Middle and Western areas were 0.37% (95% CI: 0.21%-0.53% ), 0.67% (95% CI: 0.40%-0.94% ) and 0.31% (95%CI: 0.20%-0.42% ) respectively. The prevalence rates of anti-HCV for the three areas did not show significant differences, statistically. The prevalence rate of anti-HCV in the South and North areas were 0.29%(95%CI:0.21%-0.52%) and 0.53% (95%CI:0.38%-0.64%)respectively.Conclusion Our data revealed that China was in the low prevalence area for hepatitis C infection and the results also suggested that the comprehensive measures for HCV control and prevention had been successfully achieved in the country.
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