文章摘要
李晓蕾,于锋,张永,仇锦春,刘思婷,廖清船.5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性 关系的Meta分析[J].中华流行病学杂志,2011,32(10):1030-1036
5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性 关系的Meta分析
Study on the association between 5, 10-methylenetrahydrofolate reductase C677T polymorphism and acute lymphoblastic leukemia risk: a Meta-analysis
收稿日期:2011-05-05  出版日期:2014-09-11
DOI:1 0.3760/cma.j.issn.0254-6450.2011. 10.018
中文关键词: 急性淋巴细胞白血病;5,10-亚甲基四氢叶酸还原酶;基因多态性;Meta分析
英文关键词: Acute lymphoblastic leukemia;5, 10-methylenetrahydrofolate reductase;Gene polymorphism;Meta-analysis
基金项目:
作者单位E-mail
李晓蕾 中国药科大学临床药学教研室 南京 210009  
于锋 中国药科大学临床药学教研室 南京 210009  
张永 南京医科大学附属南京儿童医院  
仇锦春 南京医科大学附属南京儿童医院  
刘思婷 南京医科大学附属南京儿童医院  
廖清船 南京医科大学附属南京儿童医院 lqc730220@126.com 
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中文摘要:
      目的 运用Meta分析的方法综合评价5,10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与急性淋巴细胞白血病(ALL)的相关性。方法 制定原始文献的纳入和排除标准及检索策略。检索中外文数据库,收集有关MTHFR基因C677T多态性与ALL相关性的研究报告,采用TT/CC+CT以及TT/CC基因型比较模型进行定量综合分析,然后按年龄(儿童或成年人) 分亚组进行分析。结果 综合分析显示,MTHFR基因677位点TT/CC+ CT、TT/CC模型计算OR值(95%CI)分别为0.87(0.69~1.09)、0.82(0.63~ 1.06);在儿童组TT/CC+ CT、TT/CC模型计算OR 值(95%CI)分别为0.92(0.79~1.08)、0.88(0.75~1.05),在成年人组TT/CC+CT、TT/CC模型计算 OR值(95%CI)分别为0.45(0.26 ~0.77)、0.41(0.22~0.72)。结论 MTHFR基因C677T突变与儿 童ALL无关联,但可能减弱成年人ALL发生的危险。
英文摘要:
      To evaluate the association between polymorphism of 5, 10- methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL). Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs. CC + CT or TT vs. CC through Meta-analysis. Stratified analysis was carried out according to different age groups (children or adult). Results In systematical analysis, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.87 (0.69-1.09 ) and 0.82 ( 0.63-1.06 ) respectively; in children' s group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.92 ( 0.79-1.08), 0.88 ( 0.75-1.05 ) while in adult group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.45 (0.26-0.77), and 0.41 (0.22-0.72) respectively. Conclusion The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL.
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