文章摘要
邓爱萍,张永慧,孙立梅,曾汉日,黎薇,柯昌文,何剑峰,马聪,林锦炎.广东省健康人群手足口病病原隐性感染状况调查[J].中华流行病学杂志,2012,33(2):189-191
广东省健康人群手足口病病原隐性感染状况调查
Survey on the recessive infection of pathogen to hand-foot-mouth disease among healthy adults 、and children in Guangdong province
收稿日期:2011-09-06  出版日期:2014-09-10
DOI:
中文关键词: 肠道病毒71型;柯萨奇病毒A16型;手足口病;隐性感染
英文关键词: Enterovirus 71;Coxsackie virus A16;Hand-foot-mouth disease;Recessive infection
基金项目:广东省医学科研指令性课题(C2010016)
作者单位E-mail
邓爱萍 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
张永慧 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
孙立梅 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
曾汉日 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
黎薇 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
柯昌文 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
何剑峰 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
马聪 广东省疾病预防控制中心传染病防治研究所, 广州 510300  
林锦炎 广东省疾病预防控制中心传染病防治研究所, 广州 510300 linjy1957@sohu.com 
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中文摘要:
      目的 了解广东省健康人群手足口病病原隐性感染情况。方法 在广东省7个市随机抽取7个年龄组健康儿童及成年人, 采集粪便标本进行手足口病病原检测。结果 7个市共采集1285份样本, 肠道病毒71型(EV71)阳性率为0.39%(5/1285), 柯萨奇病毒A组16(CA16)阳性率为0.23%(3/1285), 其他肠道病毒阳性率为7.00%(90/1285)。4~6岁年龄组EV71阳性率最高, 为1.79%(4/223), 其次为0~3岁年龄组, 为0.67%(1/223), 其余年龄组均未检出EV71;只有4~6岁年龄组检出CA16, 阳性率为1.35%(3/223)。所有EV71阳性标本均在本地户籍人群中检出, 阳性率为0.47%(5/1063);CA16在本地户籍人群(0.19%)和外地户籍(0.85%)中均有检出, 差异无统计学意义(P>0.05)。农村和城市EV71的阳性率分别为0.36%和0.54%, 差异无统计学意义(_P>0.05);所有CA16阳性标本均在城市儿童中检出。结论 广东省健康人群中仅6岁以下年龄组检出EV71和CA16阳性, 健康成年人中未检出EV71和CA16阳性, 应重点对儿童尤其是学龄前儿童采取有效防控措施。
英文摘要:
      Objective To understand the pathogen-carrying status of hand-foot-mouth disease(HFMD) among healthy people in Guangdong province. Methods Stool specimens were collected randomly on 7 age groups from 7 cities in Guangdong province. Real-time RT-PCR was used to detect enterovirus(EV), enterovirus 71(EV71) and coxsackie virus A16(CA16). Results Altogether, 1285 stool specimens were collected. The positive rates of EV71, CA16 and other enterovirus were 0.39%(5/1285), 0.23%(3/1285) and 7.00%(90/1285), respectively. The highest EV71 positive rate(1.79%) was among the 4-6-year-old group, followed by the age group 0-3 with positive rate as 0.67%. EV71 was not found among the rest age groups. The highest CA16 positive rate(1.35%) was among the 4-6 year-olds group, but the CA16 was not found among the rest age groups. EV71 was only found among native population, with the positive-rate as 0.47%. CA16-positive rate was 0.19% among the native population and 0.85% among floating population, with no significant difference found(P>0.05). The EV71 positive rate was 0.36% among rural residents and 0.54% among urban residents, but with no significant difference(P>0.05). All CA16 was found among the urban residents. Conclusion Recessive infection of EV71 and CA16 were only found among 0-6 year-old group but not found among other groups, which suggested that the approaches on prevention and control should be targeted to all children especially on pre-school children.
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