| 邓爱萍,张永慧,孙立梅,曾汉日,黎薇,柯昌文,何剑峰,马聪,林锦炎.广东省健康人群手足口病病原隐性感染状况调查[J].中华流行病学杂志,2012,33(2):189-191 |
| 广东省健康人群手足口病病原隐性感染状况调查 |
| Survey on the recessive infection of pathogen to hand-foot-mouth disease among healthy adults 、and children in Guangdong province |
| 收稿日期:2011-09-06 出版日期:2014-09-10 |
| DOI： |
| 中文关键词: 肠道病毒71型 柯萨奇病毒A16型 手足口病 隐性感染 |
| 英文关键词: Enterovirus 71 Coxsackie virus A16 Hand-foot-mouth disease Recessive infection |
| 基金项目:广东省医学科研指令性课题(C2010016) |
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| 中文摘要: |
| 目的 了解广东省健康人群手足口病病原隐性感染情况。方法 在广东省7个市随机抽取7个年龄组健康儿童及成年人, 采集粪便标本进行手足口病病原检测。结果 7个市共采集1285份样本, 肠道病毒71型(EV71)阳性率为0.39%(5/1285), 柯萨奇病毒A组16(CA16)阳性率为0.23%(3/1285), 其他肠道病毒阳性率为7.00%(90/1285)。4~6岁年龄组EV71阳性率最高, 为1.79%(4/223), 其次为0~3岁年龄组, 为0.67%(1/223), 其余年龄组均未检出EV71；只有4~6岁年龄组检出CA16, 阳性率为1.35%(3/223)。所有EV71阳性标本均在本地户籍人群中检出, 阳性率为0.47%(5/1063);CA16在本地户籍人群(0.19%)和外地户籍(0.85%)中均有检出, 差异无统计学意义(P>0.05)。农村和城市EV71的阳性率分别为0.36%和0.54%, 差异无统计学意义(_P>0.05);所有CA16阳性标本均在城市儿童中检出。结论 广东省健康人群中仅6岁以下年龄组检出EV71和CA16阳性, 健康成年人中未检出EV71和CA16阳性, 应重点对儿童尤其是学龄前儿童采取有效防控措施。 |
| 英文摘要: |
| Objective To understand the pathogen-carrying status of hand-foot-mouth disease(HFMD) among healthy people in Guangdong province. Methods Stool specimens were collected randomly on 7 age groups from 7 cities in Guangdong province. Real-time RT-PCR was used to detect enterovirus(EV), enterovirus 71(EV71) and coxsackie virus A16(CA16). Results Altogether, 1285 stool specimens were collected. The positive rates of EV71, CA16 and other enterovirus were 0.39%(5/1285), 0.23%(3/1285) and 7.00%(90/1285), respectively. The highest EV71 positive rate(1.79%) was among the 4-6-year-old group, followed by the age group 0-3 with positive rate as 0.67%. EV71 was not found among the rest age groups. The highest CA16 positive rate(1.35%) was among the 4-6 year-olds group, but the CA16 was not found among the rest age groups. EV71 was only found among native population, with the positive-rate as 0.47%. CA16-positive rate was 0.19% among the native population and 0.85% among floating population, with no significant difference found(P>0.05). The EV71 positive rate was 0.36% among rural residents and 0.54% among urban residents, but with no significant difference(P>0.05). All CA16 was found among the urban residents. Conclusion Recessive infection of EV71 and CA16 were only found among 0-6 year-old group but not found among other groups, which suggested that the approaches on prevention and control should be targeted to all children especially on pre-school children. |
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