文章摘要
于胜波,赵庆彦,崔红营,秦牧,刘韬,孔彬,黄鹤,黄从新.慢性收缩性心力衰竭患者药物治疗情况调查及相关因素分析[J].中华流行病学杂志,2012,33(2):229-233
慢性收缩性心力衰竭患者药物治疗情况调查及相关因素分析
Investigation on the prevalence and related factors of medicinal therapy in patients with chronic systolic heart failure
收稿日期:2011-08-05  出版日期:2014-09-10
DOI:
中文关键词: 心力衰竭;慢性收缩性;药物治疗;年龄;性别
英文关键词: Chronic systolic heart failure;Medicine therapy;Age;Gender
基金项目:国家自然科学基金(81070144)
作者单位E-mail
于胜波 武汉大学人民医院心内科, 武汉 430060  
赵庆彦 武汉大学人民医院心内科, 武汉 430060  
崔红营 武汉大学人民医院心内科, 武汉 430060  
秦牧 武汉大学人民医院心内科, 武汉 430060  
刘韬 武汉大学人民医院心内科, 武汉 430060  
孔彬 武汉大学人民医院心内科, 武汉 430060  
黄鹤 武汉大学人民医院心内科, 武汉 430060  
黄从新 武汉大学人民医院心内科, 武汉 430060 huangcongxin@yahoo.com.cn 
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中文摘要:
      目的 分析湖北省慢性收缩性心力衰竭(心衰)患者药物治疗分布及其影响因素。方法 回顾性调查和分析2000—2010年湖北省8市12家三级甲等医院心衰住院患者资料, 根据年龄、性别和随访结果分组, 分析不同组间药物治疗种类和药费的分布差异。对药物治疗年费用进行log1()对数转换。结果 (1)共16681例心衰患者纳人研究, 随访期间有6453例死亡。死亡组药物治疗年费用低于存活组(3.19±0.65*?. 血管紧张素受体阻滞剂使用率随年龄增加而增加;而地高辛、利尿剂、p受体阻滞剂、血管紧张素转化酶抑制剂使用率随年龄增加呈倒“U”形分布。不同年龄组药物治疗存在性别差异。(3)随着患者年龄增加药物治疗费用有增加趋势(<30, 30~、40~、50~、60~和70~79岁组分别为2.96±0.70、3.09±0.62、3.15±0.58、3.30±0.59、3.25±0.58和3.35±0.60, 尸<0.01), 而年龄彡80岁组减低至50~岁组水平。男性患者药物治疗费的分布与全部患者水平相似, 而女性患者在<30、30~和40~岁组间无差异, 在其他年龄组的分布与全部患者水平相似。结论 湖北省心衰患者药物治疗有待改善, 药物治疗受年龄、性别影响, 其中女性患者药物治疗情况较男性差。
英文摘要:
      Objective To investigate the prevalence and related factors of medicinal therapy in patients with chronic systolic heart failure(CSHF). Methods Data on in-hospital patients with CSHF were studied from 12 hospitals in Hubei province, in 2000 and 2010. Differences on gender and age were calculated and Multivariate Cox regression analysis was performed to determinate the independent risk factors of all-cause mortality. Results(1) 16 681 patients were enrolled in this study. Among which, 6453 died during the 5.82 土 1.63 years of follow-up. The annual medical expenditure was larger in the survival group than in the dead ones(3.19 土 0.65 vs. 3.32 土 0.57, 0.01).(2) The prevalence of Angiotensin II receptor blocker increased along with age which accounted as 7.73%, 7.35%, 12.26%, 14.29%, 17.19%, 19.87% and 20.49%, respectively, in the <30, 30-39, 40-49, 50-59, 60-69, 70-79 and 多 80-year groups. The distribution of digitalis, diuretics, P-receptor blocker, Angiorensin- converting enzyke inhibitors showed inversed U shape.(3) The annual medical expenditure increased as patients got older, with age groups <30, 30-39, 40-49, 50-59, 60-69 and 70-79 years old as 2.96 士 0.70, 3.09 土 0.62, 3.15 土 0.58, 3.30 士 0.59 and 3.25 土 0.58, respectively(P<0.01). It reduced to the same level as in the 50-59 year-old group. The distribution of annual medical expenditure showed similar pattern in males. However, the trends were only found in patients at 50-59, 60-69, 70-79 and ^80 years-old groups in female. Conclusion More attention should be paid to medicinal therapy in patients with CSHF. Medicinal therapy shifted with age and gender, of which females had more adverse trend than in males.
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