文章摘要
王敬军,魏战臻,魏菁,马长安,董建华,卢晓玲,郑媛,余鹏博,屈建会,董丽芳.陕西省肾综合征出血热疫区人群国产疫苗免疫远期效果分析[J].中华流行病学杂志,2012,33(3):309-312
陕西省肾综合征出血热疫区人群国产疫苗免疫远期效果分析
Long term epidemiological effects of vaccination on hemorrhagical fever with renal syndrome (HFRS) in Shaanxi provincial HFRS epidemic areas
  
DOI:
中文关键词: 肾综合征出血热疫苗;抗体;保护率
英文关键词: Hemorrhagical fever with renal syndrome vaccination;Antibody;Protective rate
基金项目:
作者单位E-mail
王敬军 陕西省疾病预防控制中心, 西安 710054 jingjunwang@china.com 
魏战臻 户县疾病预防控制中心  
魏菁 陕西省疾病预防控制中心, 西安 710054  
马长安 户县疾病预防控制中心  
董建华 陕西省疾病预防控制中心, 西安 710054  
卢晓玲 户县疾病预防控制中心  
郑媛 陕西省疾病预防控制中心, 西安 710054  
余鹏博 陕西省疾病预防控制中心, 西安 710054  
屈建会 户县疾病预防控制中心  
董丽芳 陕西省疾病预防控制中心, 西安 710054  
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中文摘要:
      目的 研究肾综合征出血热(HFRS)疫苗远期保护率,分析疫苗接种后抗体变化规律.方法 采取整群、随机抽样和横断面调查方法,在陕西省HFRS疫区(户县)和非疫区(定边县)开展发病和疫苗接种调查,采用ELISA检测血清IgG抗体.结果 HFRS疫苗保护率拟合接种年限的曲线方程[保护率Y=(0.863+ 0.283/X年限)×100%],末次接种7~8年后保护率降到90%以下,10年后为88%,平均94%;疫区接种人群IgG检测吸光度(A)中位数高于疫区非接种人群4倍,完成基础免疫接种即可获得较高抗体水平,末次接种5~ 10年间抗体水平下降50%,10年以后下降60%.结论 在HFRS疫区,人群抗体在末次接种后5~10年间下降50%,疫苗保护率在7~8年后降到90%以下,可考虑7年后再加强接种一个针次.
英文摘要:
      Objective To evaluate the protective rate and the variation of HFRS-IgG on hemorrhagical fever with renal syndrome (HFRS) vaccine.Methods Cluster,random sampling and cross-sectional study were used to assess the protective rate of HFRS vaccination.Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS.Results Curve equation was obtained as Yprocective rate=(0.863+0.283/Xvaccination term) × 100% by protective rate with vaccination term.Protective rates showed a reducing trend,90% after 7-8 years of vaccination,88% after 10 years,and 94% on average.Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without,in the epidemic area.Higher antibody level could be obtained after primary vaccination,but the level of antibody had a 50% reduction after 5-10 years of vaccination,and a 60% reduction after 10 years of vaccination.Conclusion HFRS antibody had a 50% reduction after 5-10 years of vaccination.The protective rate of HFRS vaccination had a 90% loss,after 7-8 years of vaccination.Booster dose was necessary after 7 years of vaccination.
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