| 王敬军,魏战臻,魏菁,马长安,董建华,卢晓玲,郑媛,余鹏博,屈建会,董丽芳.陕西省肾综合征出血热疫区人群国产疫苗免疫远期效果分析[J].中华流行病学杂志,2012,33(3):309-312 |
| 陕西省肾综合征出血热疫区人群国产疫苗免疫远期效果分析 |
| Long term epidemiological effects of vaccination on hemorrhagical fever with renal syndrome (HFRS) in Shaanxi provincial HFRS epidemic areas |
| 收稿日期: 出版日期:2014-09-09 |
| DOI： |
| 中文关键词: 肾综合征出血热疫苗 抗体 保护率 |
| 英文关键词: Hemorrhagical fever with renal syndrome vaccination Antibody Protective rate |
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| 中文摘要: |
| 目的 研究肾综合征出血热(HFRS)疫苗远期保护率,分析疫苗接种后抗体变化规律.方法 采取整群、随机抽样和横断面调查方法,在陕西省HFRS疫区(户县)和非疫区(定边县)开展发病和疫苗接种调查,采用ELISA检测血清IgG抗体.结果 HFRS疫苗保护率拟合接种年限的曲线方程[保护率Y=(0.863+ 0.283/X年限)×100％],末次接种7～8年后保护率降到90％以下,10年后为88％,平均94％；疫区接种人群IgG检测吸光度(A)中位数高于疫区非接种人群4倍,完成基础免疫接种即可获得较高抗体水平,末次接种5～ 10年间抗体水平下降50％,10年以后下降60％.结论 在HFRS疫区,人群抗体在末次接种后5～10年间下降50％,疫苗保护率在7～8年后降到90％以下,可考虑7年后再加强接种一个针次. |
| 英文摘要: |
| Objective To evaluate the protective rate and the variation of HFRS-IgG on hemorrhagical fever with renal syndrome (HFRS) vaccine.Methods Cluster,random sampling and cross-sectional study were used to assess the protective rate of HFRS vaccination.Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS.Results Curve equation was obtained as Yprocective rate=(0.863+0.283/Xvaccination term) × 100％ by protective rate with vaccination term.Protective rates showed a reducing trend,90％ after 7-8 years of vaccination,88％ after 10 years,and 94％ on average.Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without,in the epidemic area.Higher antibody level could be obtained after primary vaccination,but the level of antibody had a 50％ reduction after 5-10 years of vaccination,and a 60％ reduction after 10 years of vaccination.Conclusion HFRS antibody had a 50％ reduction after 5-10 years of vaccination.The protective rate of HFRS vaccination had a 90％ loss,after 7-8 years of vaccination.Booster dose was necessary after 7 years of vaccination. |
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