文章摘要
黄启涛,钟梅,王晨虹,陈敦金,刘正平,黎静,王硕石,汪丽萍,宋天蓉,郭雪菁,冷灵芝,罗小华,刘建,秦竞霞,梁海英,刘丽娜.广东省不同地域孕产妇围生期栓塞性疾病流行病学调查[J].中华流行病学杂志,2012,33(4):413-417
广东省不同地域孕产妇围生期栓塞性疾病流行病学调查
Prevalence and major risk factors of peripartum thromboembolic disease in different regions of Guangdong province
收稿日期:2011-11-15  出版日期:2014-09-09
DOI:
中文关键词: 深静脉血栓  颅内静脉血栓  发生率  危险因素
英文关键词: Deep vein thrombosis  Cerebral venous thrombosis  Prevalence  Risk factors
基金项目:广东省科技计划项目(2007B030502015)
作者单位E-mail
黄启涛 南方医科大学附属南方医院妇产科, 广州 510515  
钟梅 南方医科大学附属南方医院妇产科, 广州 510515 zhongmei@fimmu.com 
王晨虹 深圳市妇幼保健院  
陈敦金 广州医学院第三附属医院妇产科广州市危重症孕产妇救治中心  
刘正平 佛山市妇幼保健院  
黎静 南方医科大学附属南方医院妇产科, 广州 510515  
王硕石 南方医科大学附属南方医院妇产科, 广州 510515  
汪丽萍 南方医科大学附属南方医院妇产科, 广州 510515  
宋天蓉 广州医学院第三附属医院妇产科广州市危重症孕产妇救治中心  
郭雪菁 佛山市顺德区人民医院  
冷灵芝 深圳市妇幼保健院  
罗小华 清远市人民医院  
刘建 粤北人民医院  
秦竞霞 佛山市妇幼保健院  
梁海英 新会市妇幼保健院  
刘丽娜 清新县人民医院  
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中文摘要:
      目的 探讨广东省不同地域孕产妇围生期栓塞性疾病发病情况、流行病学特征及相关高危因素.方法 回顾性调查2005年1月至2010年6月广东省珠三角及粤东、西、北地区13家三甲医院共169218名孕产妇病历资料,分析妊娠期或产褥期栓塞性疾病的发病率及其流行病学特征.结果 (1)169 218名孕产妇中,栓塞性疾病共201例,发生率为1.3‰,其中妊娠或产褥期合并下肢深静脉血栓形成(DVT) 128例,合并颅内静脉窦血栓形成(CVT)68例,合并肺栓塞5例,发生率分别为0.8‰、0.4%、0.02‰.(2)珠三角地区孕产妇DVT发生前5位高危因素主要为既往血栓病史或血栓家族史、妊娠合并症、妊娠合并内科疾病、卧床时间>3d、孕期体重增长>15kg;粤东、西、北地区孕产妇DVT发生前5位高危因素主要为孕期体重增长>15kg、卧床时间>3d、子痫前期、剖宫产手术、妊娠合并症.珠三角地区孕产妇CVT发生前5位高危因素主要为子痫、子痫前期、妊娠合并症、卧床时间>3 d、既往血栓病史或血栓家族史;粤东、西、北地区孕产妇CVT发生前5位高危因素主要为子痫、子痫前期、高龄或低龄妊娠、孕期体重增长>15 kg、妊娠合并症.结论 不同地域围生期栓塞性疾病的发病率及危险因素存在着一定差异;对不同地域栓塞性疾病发病特点及发病高危因素采取有效措施,是预防和降低疾病发生的重要手段.
英文摘要:
      Objective To investigate the prevalence and major risk factors of peripartum thromboembolic disease in different regions of Guangdong province.Methods Data from 169 218pregnant women in different regions of Guangdong province from January 2005 to June 2010 were analyzed retrospectively.The prevalence and epidemiological characteristics of thromboembolic disease during pregnancy or puerperium were investigated.Results Of the studied population,( 1 )20 l cases ( 1.3‰ ) suffered from thromboembolic disease during pregnancy or puerperium including 128 cases of deep vein thrombosis (DVT),68 cases of cerebral venous thrombosis (CVT) and 5pulmonary embolism,the prevalence rates were 0.8‰,0.4‰,and 0.02‰ respectively.(2) Risk factors in different regions showed that,in the Pearl River Delta area,the major risk factors for DVT would include previous or family history of thrombosis,pregnancy complications,with medically involved diseases,prolonged bed rest and pregnancy weight gain > 15 kg etc.While in castern,western,northern parts of Guangdong,the major risk factors for DVT would include pregnancy weight gain > 15 kg,prolonged bed rest,preeclampsia,cesarean section and complications during pregnancy.In Pearl River Delta region,the major risk factors for CVT would include eclampsia,preeclampsia,pregnancy complications,prolonged bed rest >3 days,past history or family history of thrombosis.While eclampsia,preeclampsia,advanced age or younger age,pregnancy weight gain >15 kg,complications during pregnancy were the major risk factors for CVT in the eastern,western or northem parts of Guangdong.Conclusion Prevalence and major risk factors of peripartum thromboembolic disease in different regions of Guangdong were different.It was crucial to take effective measures in pregnant women with different epidemiological characteristics and risk factors to prevent and reduce the incidence of peripartum thromboembolic disease.
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