文章摘要
张晓婷,赵冬,刘静,冯立群,孙佳艺,王淼,刘军,王薇.北京市中老年人群甘油三酯水平与颈动脉新发斑块关系的研究[J].中华流行病学杂志,2012,33(5):455-459
北京市中老年人群甘油三酯水平与颈动脉新发斑块关系的研究
Association between both triglyceride level,newly identified carotid plaque and middle-aged and elderly population.Beijing
收稿日期:2011-12-15  出版日期:2014-11-03
DOI:
中文关键词: 甘油三酯;颈动脉斑块;血脂异常;动脉粥样硬化
英文关键词: glyceride;Carotid plaque;Dyslipidemia;Atherosclerosis
基金项目:“十一五”国家科技支撑计划(2006BAl01A02);国家自然科学基金(81170266,81070226,81000109)
作者单位E-mail
张晓婷 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029
神经内科
延边大学医学部内科系 
 
赵冬 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029  
刘静 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029  
冯立群 神经内科  
孙佳艺 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029  
王淼 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029  
刘军 神经内科  
王薇 医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室, 首都 100029 weiwuang@sohu.com 
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中文摘要:
      目的探讨甘油三酯(TG)水平与北京市中老年人群5年颈动脉新发斑块的关系。分析TG合并心血管疾病传统危险因素对颈动脉新发斑块的预测作用。方法应用队列研究方法,选取北京市两社区人群TG指标和基线复查两次颈动脉超声检测数据完整者共1949人作为研究对象。将基线TG分为4组:组1(<1。13 mmol/L)、组2(1。13—1。69mmoFL)、组3(1。70—2。 25retool/L)及组4(≥2。 26mmol/L),以颈动脉新发斑块作为动脉粥样硬化进展的评价指标,分析基线TG水平与颈动脉新发斑块的关系。结果不同TG水平组问新发斑块率比较,新发斑块率随着基线TG水平的上升而增加(分别为30。8%、38。8%、41。9%和44。 2%。x2=21。22,P结论北京市中老年人群颈动脉新发斑块率随着基线TG水平的上升而增加。高TB(≥2。 26 mmoFL)可增加中老年人群颈动脉新发斑块的危险。
英文摘要:
      ObjectiveTo evaluate the association between triglyceride(TG)level and newly identified 5-year carotid plaque and to explore the prediction value of TG 1evel on the newly—identified carotid plaque with risk factors of traditional atherosclerosis.Methods A cohort study was adopted.The baseline survey including CVD risk factors and B-mode ultrasound of carotid artery was performed in 2002 and the second followUp-examination was performed in 2007. e evaluated 1949 participants with lipid measurements and B—mode ultrasound of carotid arteriesin the two surveys(with mean age as 57. 9±8.1 years and 39.2% were men).The baseline TG levels were divided into four groups:groupl(TG<1.13mmol/L).group2(TG=1.13-1.69mmol/L),group3(TG=1.70一2. 25 mmoI/L)and group 4(TG≥2. 26mmol/L).Newly idenfified carotid plaque was regarded as the indicator of progression of carotid atherosclerosis.New relationship between fasting TG levels and newly identified carotid plaque was analysed.Results Compared to newly identified carotid plaque which including different TG level groups,the incidence of newly artery plaque had significantly increased a long with the increase of baseline triglyceride 1evel(30.8%.38.8%,41.9% and 44. 2%respectively.with x2=21.22. P2. 26 mmol/L)appeared a significant independent predictor of newly identified carotid plaque(OR-----1.37,95%C/:1.00一1.86).When further stratifying the traditional a therosclerosis risk factors,we found that high TG group with smoking or hypertension was an independent factor of atherosclerosis progression.Conclusion with the increase of trigly ceride levels,the rate of newly identified carotid plaqueal so increased.After adjusting age,sex,dyslipidemia and other risk factors.serum fasting TG≥2. 26 mmoI/Lappeared to be anindependent predictorof newly developed carotid plaque.
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