文章摘要
郑艳敏,王燕,赵静,戴以恒,罗晓明,沈宗姬,陈昕,袁伟,沈月平.血清双酚A含量与复发性流产的1:2病例对照研究[J].中华流行病学杂志,2012,33(8):841-845
血清双酚A含量与复发性流产的1:2病例对照研究
Association between Sel'nm bisphen01.A and recurrent spontaneous abortion:a 1:2 case-control study.China
收稿日期:2012-03-20  出版日期:2014-09-03
DOI:
中文关键词: 复发性流产  双酚A  病例对照研究
英文关键词: Recurrent spontaneous abortion  Bisphenol A  Case-control study
基金项目:国家大学生创新性实验计划项目(5731503110)
作者单位E-mail
郑艳敏 苏州大学医学部公共卫生学院流行病与卫生统计教研室 215123  
王燕 苏州大学医学部公共卫生学院流行病与卫生统计教研室 215123  
赵静 苏州大学医学部公共卫生学院放射医学 215123  
戴以恒 苏州大学医学部公共卫生学院放射医学 215123  
罗晓明 苏州大学医学部公共卫生学院放射医学 215123  
沈宗姬 江苏省昆山市妇幼保健所  
陈昕 苏州大学附属第一人民医院妇产科  
袁伟 苏州大学附属第一人民医院附属第二人民医院妇产科  
沈月平 上海计划生育科学研究所 syp_shen@yahoo.com.cn 
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中文摘要:
      目的 探讨血清中双酚A含量与不明原因复发性流产的关系。方法 采用以医院为基础的1:2病例对照研究,对62例不明原因复发性流产者按年龄±2岁、同一地区、同一孕周进行匹配。以柱前荧光-高效液相色谱法检测62例不明原因复发性流产者(病例组)和108名正常怀孕妇女(对照组)血清中双酚A的含量。按年龄、体重指数(BMI)、孕周、文化程度、职业分布和吸烟状况进行分组比较。结果 病例组和对照组血清双酚A含量(中位数±四分位数间距)分别是(0.009±0.002)、(0.004±0.012)μg/ml,差异有统计学意义(Z=3.506,P=0.0005)。在调整年龄、职业、文化程度、BMI、被动吸烟等因素后,以双酚A浓度≤0.004 μg/ml为参比,双酚A浓度在0.004~0.012 μg/ml之间的OR值为4.39(95%CI:1.15~16.71),双酚A浓度≥0.012 μg/ml的OR值为4.95(95%CI:1.77~13.82),且随着双酚A水平的升高,发生复发性流产的风险也在增加(P=0.0024);经秩转换方差分析SNK法检验发现,正常妊娠者、复发性流产2次与≥3次者之间差异有统计学意义(双酚A含量分别为0.004、0.008、0.018μg/ml,F=8.92,P=0.0002)。结论 血清中高水平的双酚A含量可能与不明原因复发性流产之间存在关联。
英文摘要:
      Objective This study was to investigate the association between serum Bisphenol-A(BPA) and unexplained recurrent spontaneous abortion(RSA).Methods A hospitalbased 1 ∶ 2 matched case-control study was conducted.Sixty-two patients with unexplained recurrent abortion were included and matched with 2 normal controls by factors as age(± 2 years),living in the same district and the same gestational age.The levels of BPA in serum for 62 cases and 108 controls were detected under high performance liquid chromatography after fluorescent derivatization.Levels of serum BPA in each case was compared with that in control of age,BMI,education levels,occupation,exposure for passive smoking.Results The values of serum BPA in cases and controls were(0.009 ± 0.002) and(0.004 ± 0.012) μg/ml,respectively.The levels of serum BPA in cases was significantly higher than in controls(Z=3.506,P=0.0005).After adjusted by age,BMI,education levels,occupation,passive smoking history and other factors,when compared to BPA below 0.004 μg/ml.The adjusted ORs were 4.39(1.15-16.71)for BPA levels between 0.004 μg/ml and 0.012 μg/ml,and 4.95(1.77-13.82) for BPA over 0.012 μg/ml.The risk of unexplained recurrentspontaneous abortion increased progressively with the growth of serum BPA levels(x2 =9.179,trend test P=0.0024).There were significant differences on BPA among controls that with histories of two,three or more abortions(the levels were 0.004,0.008,0.018 μ g/ml,respectively,F=8.92,P=0.0002).Conclusion High BPA level might be associated with unexplained recurrent spontaneous abortion.
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