文章摘要
马艳荣,徐焱成,葛家璞.胰岛素治疗的1型糖尿病患者加用阿卡波糖后血糖波动改善的疗效观察[J].中华流行病学杂志,2012,33(8):854-856
胰岛素治疗的1型糖尿病患者加用阿卡波糖后血糖波动改善的疗效观察
Improvement in blood Oucose fluctuations of insulin-treated type 1 diabetic patients with additional use of acarbose and assessed by continuous blood gIucoele monitoring program
收稿日期:2012-05-25  出版日期:2014-09-03
DOI:
中文关键词: 1型糖尿病  阿卡波糖  动态血糖监测系统
英文关键词: Type l diabotes  Acarbose  Contmuous glucose monitoring
基金项目:
作者单位E-mail
马艳荣 武汉大学中南医院内分泌科 430000
新疆维吾尔自治区人民医院内分泌科 
 
徐焱成 武汉大学中南医院内分泌科 430000 xuyancheng111@163.com 
葛家璞 新疆维吾尔自治区人民医院内分泌科  
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中文摘要:
      目的 观察胰岛素强化治疗的1型糖尿病患者应用阿卡波糖后血糖波动改善情况。方法 120例患者随机分为对照组和观察组,对照组采用三餐超短效胰岛素加睡前长效胰岛素治疗,观察组在对照组的基础上,给予三餐时口服阿卡波糖50 mg,比较两组患者血糖波动、餐后血糖漂移及夜间低血糖情况。结果 观察组平均血糖为(9.37±1.70) mmol/L,最大血糖波动幅度(LAGE)为(11.42±2.73) mmol/L、高血糖曲线下面积(AUC)为0。89±0.54、平均血糖波动幅度(MAGE)为(5.13±2.23) mmol/L、M值为(18.93±11.43)mmol/L、胰岛素用量为(42.11±14.42)U/d,上述结果均显著低于对照组(P<0.05);此外,餐后血糖漂移情况明显低于对照组(P<0.05);夜间低血糖次数为(0.33±0.50)/d,持续时间为(43.75±43.50)min,低血糖指数(LBGI)为(0.005±0.002)mmol/L均明显低于对照组,结果具有统计学意义(P<0.05)。结论 阿卡波糖治疗可明显改善1型糖尿病患者的血糖波动,降低胰岛素用量,减少血糖漂移和夜间低血糖情况,值得临床推广。
英文摘要:
      Objective To investigate the effect of combined use of insulin and acarbose on glucose excursion in type 1 diabetic patients.Methods 120 cases were randomly divided into control group and observation group.The control group received preprandial ultra-short effect insulin and long-acting insulin before bedtime while the observation group received acarbose 50 mg added to the medicine taken by the control group.Continuous Glucose Monitoring System(CGMS) was used to watch the blood glucose fluctuations.Data related to blood glucose level,glucose excursions after meals and hypoglycemia at night were compared between patients in the two groups.Results The average blood glucose(9.37 ± 1.70) mmol/L,the largest amplitude of glycemic excursions(LAGE)(11.42 ± 2.73) mmol/L,hyperglycemia-area under curve 0.89 ± 0.54,mean amplitude of glycemic excursions(MAGE)(5.13 ± 2.23) mmol/L,M-value(18.93 ± 11.43) mmol/L and insulin dosage(42.11 ± 14.42)U/day of observation group were significantly lower than in the control group(P<0.05).Glucose excursions after meals and the times(0.33 ± 0.50)/day,the maintenance time(43.75 ± 43.50)/min and low glycemic index(LBGI)(0.005 ± 0.002) mmol/L of hypoglycemia at night were also significantly lower than in the control group,with statistically significant(P<0.05) differences.Conclusion The blood glucose fluctuation was significantly improved,with the decrease of insulin dosage while both glucose excursions and hypoglycemia at night reduced in patients with typel diabetes mellitus after the acarbose treatment.We suggested that this program deserve further observation.
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