| 王燕,马艳荣,李素丽,玛依努,吴岚,赵力敏,宋向欣,葛家璞,徐焱成.新疆汉族和维吾尔族糖调节受损人群胰岛素分泌及其功能的比较研究[J].中华流行病学杂志,2012,33(9):961-963 |
| 新疆汉族和维吾尔族糖调节受损人群胰岛素分泌及其功能的比较研究 |
| Secretion and action of insulin among Han and Uygur subjects with impaired fasting glucose and Impaired glucose tolerance， from Xinjiang |
| 收稿日期:2012-06-20 出版日期:2014-09-17 |
| DOI：10.3760/cma.j.issn.0254-6450.2012.09.019 |
| 中文关键词: 糖调节受损 胰岛素 |
| 英文关键词: Impaired glucose regulation Insulin |
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| 中文摘要: |
| 目的 比较新疆地区汉族和维吾尔(维)族人群空腹血糖受损(IFG)、糖耐量减低(IGT)及混合性糖调节受损(CGI，IFG/IGT)阶段胰岛素分泌及其功能。方法 2007—2008年在新疆部分地区采用多中心横断面调查(中国第三次糖尿病流行病学调查)，共计2203名研究对象(汉族1118人，维族1085人)行口服75g葡萄糖耐量试验(OGTT)，用胰岛素抵抗指数(HOMA-IR)评估胰岛素抵抗，胰岛β胞功能指数(HOMA-β)评估基础胰岛素分泌，OGTT中空腹和30min胰岛素、血糖差值的比值(Δ130/ΔG30)评价胰岛素早相分泌，Δ130/ΔG30/HOMA-IR评估葡萄糖处置指数(DI)。结果 腰围、体重指数、血脂水平、0及120 min胰岛素值在汉维两民族不同糖代谢组的差异有统计学意义。在糖凋节正常(NGT)、IFG，CGI组，维族人群的腰围要显著高于汉族(P<0.01)。在NGT、IFG、IGT组，汉族人群的120min血清胰岛素水甲则显著高于维族(P<0.01)。汉族人群的HOMA-IR、HOMA-β在小同糖代谢组均显著高于维族(P<0.01)。Δ130/ΔG30、DI在两民族不同糖代谢组间的差异无统计学意义。结论 汉族人群较维族在糖调节受损阶段有显著的胰岛素抵抗，同时存在胰岛D细胞代偿件分泌以维持血糖水平。 |
| 英文摘要: |
| Objective To compare insulin secretion and action with impaired tasting glucose (IFG), impaired glucose tolerance(IGT) and combined glucose intolerance(CGI, IFG and IGT) between Han and Uygur populations living in Xinjiang. Methods A multicenter cross-section survey (The Third Diabetes Epidemiological Survey in china) was conducted in Xinjiang from 2007 to 2008 including 2203 subjects (Han 1118, Uygur 1085) underwent an oral glucose test(OGTT). Homeostasis model assessment on insuliu resistance (HOMA-TR) and β cell function (HOMA-β) were calculated. The ratio of ineremental insulin (Δ130)and glucose (ΔG30) response was used to evaluate the early insulin secretion. Δ130/ΔG30/HOMA-IR was used to evaluate the glucose disposition index (DT). Results There were diffcrences noticed regarding the waist circumstances (WC), body mass index (BMI), 1ipids, 0 and 120 min insulin levels in different glucose tolerance status between the Hans and Uygurs. Data related to NGT, IFG, CGI, WC from the Uygurs was significantly different from that of the Hans(P< O.01)， while the NGT， IFG， IGT and 120-minme plasma insulin levels of the Hans were significantly different from that of the Uygnrs(PConclusion Regarding the regulation of impaired glucose, the insulin resistance among the Hans was significantly different from that of the Uygurs, while there seemed to be a compensatory secretion of pancreatic β cells which played the role of maintaining blood glucose homeostasis. |
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