文章摘要
朱建芳,梁黎,傅君芬,巩纯秀,熊丰,刘戈力,罗飞宏,陈少科.中国6市7~1 6岁中小学生血脂水平现状调查[J].中华流行病学杂志,2012,33(10):1005-1009
中国6市7~1 6岁中小学生血脂水平现状调查
Survey on the levels of lipids in school-aged children of Beijing,Tianjin,Hangzhou,Shanghai,Chongqing and Nanning cities
收稿日期:2012-04-11  出版日期:2014-09-03
DOI:
中文关键词: 血脂  非高密度脂蛋白胆固醇  学龄期儿童  肥胖
英文关键词: Lipids  Non-high-density lipoprotein cholesterol  Children of school-age  Obesity
基金项目:“十一五“国家科技支撑计划(2009BAl80801)
作者单位E-mail
朱建芳 浙江大学医学院附属儿童医院内分泌科, 310003 杭州  
梁黎 浙江大学医学院附属儿童医院内分泌科, 310003 杭州 zdliangli@163.com 
傅君芬 浙江大学医学院附属儿童医院内分泌科, 310003 杭州  
巩纯秀 首都医科大学北京儿童医院内分泌科  
熊丰 重庆医科大学附属儿童医院内分泌科  
刘戈力 Department ofPediatrics, Tianfin Medical University General Hospital  
罗飞宏 上海复旦大学附属儿科医院内分泌与遗传代谢科  
陈少科 广西壮族自治区妇幼保健院儿科  
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中文摘要:
      目的解中国汉族学生血脂水平现状,为制定儿童青少年血脂异常防治策略提供依据。方法选择有地域代表的北京、天津、杭州、上海、重庆和南宁6市2010年在校7~16岁中小学生共20 191名(男性10 669名,女性9522名)为调查对象;按血脂测定标准化方法测定空腹甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆同醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平,计算非高密度脂蛋白胆固醇(non-HDL-C)。结果果(1)7~16岁儿童青少年每岁年龄组的TG(95百分位数,P。,)为1.26~1.88 mmol/L,TC(P。,)为4.80~5.46 mmol/L,LDL-C(P。s)为2.67~3.27mmol/L.non-HDL-C(P。,)为3.36~3.9l mmol/L,与年龄无明甚相关性(P>0.05)HDL-C(P,)波动于1.08~0.83 mmol/L,HDL-C与年龄的相关性分析提示差异有统计学意义(P结论在儿童青少年期,年龄不是影响TG、TC、LDL-C水平的主要因素,但HDL-C水平随年龄增长有一定下降趋势;非肥胖组血脂水平明显优于肥胖组,且东郭地区优于北部及中西部。
英文摘要:
      ObjectiveTo investigate the lipid levels of Hart ethnicity Chinese children atschool-age,to provide objective data for the formnlation of prevention and management strategy regarding dyslipidemia children and adolescents.Methods20 1 9 1 children(with 1 0 669 boys and 9522 girls)aged 7 to 1 6 years old from 6 representative geographical areas,including Beijing,Tianjin,Hangzhou,Shanghai,Chongqing and Nanning,were surveyed in a randomly selectedclustered sample in China.Data on fasting blood triglyceride(TG).total cholester01(TC),low-density lipoprotein cholester01(LDL-C)and high-density lipoprotein cholesterol(HDL-C)1evelswere measured Non-high.density lipoprotein cholester01(non-HDL-C)levels were calculated with data collection,entry.and collation were under the same criteria.Results(1)In the 7-l 6 year-old group.TG(P9)fluctuated between).26 mmol/L and 1.88 mmol/L,while TC(Pqj)was between 4.80mmol/L and 5.46mmol/L.LDL-C(P95)was between 2,67mmol/L and 3.27mmol/Lwhilenon-HDL-C(P。。)was between 3.36 mmol/L and 3.9lmmol/L,sugesting that age did not seem to be an affectingfactor for the lipid 1evel(P>0.05).The level of HDL-C(P5)fluctuated bctween 1.08 mmol/L and 0.83 mmol/L.and the dependability analysis on HDL-C and age showed statistically significantdif’fefence(P<0.01.r=-0.274).(2)In the 7-9 year-old group,the levels ofTG,TC,LDL-C and non-HDL-C of boys were lower but the HDL-C level was higher than in girls.However.i11 the 1 0-l 6year-old group.the 1evels of five lipids of boys were a1110wer than in girls,with a11 the differences statistically significant(P<0.05).(3)The levels of TG,TC,LDL-C and non-HDL-C in the obesegroup were significantly higher than those in non-obesity group.as HDL-C was significantly lower than in non-obese group(P<0.0 1).Incidence rates of single and multiple dyslipidemia in obese groupwere significantly higher than in non-obese group(P<0.01).(4)Grouped by region,the abnormal rates of TG were descending,with the ranking as North(10.4%),Midwest(9.7%)and East(8 3%).while the abnormal rates of TC were descending with the ranking as Midwest(6.0%).Nonh(5.2%) and East(4.8%),The abnormal rates ofLDL-Cwere descending as the ranking of North(3.1%),East (2.6%)and Midwest(0.9%).with the abnormal rates of non-HDL-C were descending as Midwest(6.5%).North(4 2%)and East(3.6%).The abnormal rates of HDL-C were descending as Midwess (14.2%)。North(5.7%)and East(5.5%).A1l the differences in the above-said iterns were statisticallysignificant(P<0。05).(5)According to the standards ofhyperlipidemia formulated by the American Academy of Pediatrics,the incidence rates of abnormal TG,TC.LDL-C.non.HDL-C.HDL-C were 9.4%,5.4%,2.2%,4.8%,8.6%respectively.Conclusion(1)Levels of lipids were affected by many factors.but age was not one of them in children and adolescents.However.HDL-C was decliningalong with the inerease of age.to some extent(2)Giris had a relatively protective tendency through the increasing HDL-C level when they entered the puberty years.(3)Lipids levels in non-obese groupwere significantly better than the obese group.(4)The lipids 1evels of children and adolescents in the Eastern region of the country were better than that in the northern and mid-western areas.
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