| 杨黎明,李小攀,杨琛,闫蓓,张美玉,傅益飞,孙乔,曹广文.2002--2011年上海市浦东新区居民原发性肝癌发病及生存情况分析[J].中华流行病学杂志,2012,33(10):1016-1020 |
| 2002--2011年上海市浦东新区居民原发性肝癌发病及生存情况分析 |
| Incidence and survival condition of primary liver cancer among residents in Pudong district ofShanghai。from 2002to 2011 |
| 收稿日期:2012-06-15 出版日期:2014-09-03 |
| DOI： |
| 中文关键词: 原发性肝癌 发病率 死亡率 生存率 |
| 英文关键词: Primary 1iver cancer Incidence Mortality Survival rate |
| 基金项目:上海市浦东新区卫生系统重点学科建设(PWZxk2010-009) |
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| 中文摘要: |
| 目的分析上海市浦东新区原发性肝癌(PLC)患者发病和生存情况。方法以2002--2011年上海市浦东新区常住户籍居民为研究对象。计算PLC发病率及死亡率，按世界标准人口年龄构成标化后，分析不同性别、不同地区患者生存情况，同时探讨手术切除治疗对PLC预后的影响结果2002--2011年上海市浦东新区PLC新发患者7981例，其中男性5754例，女性2227例，平均发病年龄分别为60.27岁和68，26岁。合计粗发病率为30.73／10万人年，其中男性粗发病率为44.30／10万人年，高于女性的17.16／10万人年，差异有统计学意义(u=3.46.P<0.叭)；男性标化发病率为25.72／10万人年，高于女性的8.22／10万人年，差异有统计学意义(u=3，00，P结论结论上海市浦东新区男性PLC发病率和死亡率较高，农村地区患者总体生存时间较低，手术治疗可改善其预后。 |
| 英文摘要: |
| ObjectiveTo analyze the incidence and survival rates of primary liver cancer(PLC)among residents in Pudong district of Shanghai.MethodsPermanent residents of Pudong district.Shanghai were recruited in the study between 2002 and 20 11，among whom 798 1 PLC cases were diagnosed and 7233 death cases were ceaified.Both morbidity and mortality of PLC were calculated and standardized(ASR)bv the world population of 1 966.in order to analyze the survivalcondition of PLC patients on gender or address，to explore the prognosis of surgical excision treatment ResulIsAmong the incident cases of PLC between 2002 and 201 1.5754 cases weremales，with an average age of 60.27；while 2227 cases were females，with an average age of 68.26.The crude incidence rate for both sexes was 30.73 per 100 000 person-year.and was 44.30 per 100 000 person.year for males.higher than that in females.17.16 per 100 000 person year，The difference showed statistical significance(U=3.46，P<0.01).The ASR for incidence rates were 25。72 per 100000 person-year in males and 8.22 per l 00 000 person-year in females.respectively.with difference statistically significant(m=3.00。P<0.01).There were 7233 PLC death cgses in total.including 5151 males and 2082 females，with the crude mortality rate as 27.85 per 1 00 000 person-year Rate for males was 39.65 per 100 000 person-year.significantly different from 16.04 per 100 000 person-year in females，statistically(It=3.16，P<0.01).The ASRs for mortality were 22.77 per 100000person-year in males and 7.39 per lOO000 person.year in females.with statistically significant difkrence(u=2.80.Jp<0.01).Both incidence and mortality rates increased apparently for males aged over 35 and females aged over 45.The 1-to 5-year survival rates of PLC were l 9.88％.1 4.9 l％.12.19％.10.29％and 8.56％.respectively There were statistically significant differences among urban，town and tllral areas in the over-all survival rates(x2=8.71 1，P=0.013)：The difierences in 1-to 5-yearsurvival rates between surgical and non.surgicaI groups showed statistically significant diffe：rences(u=10.8，6.93，4.75，3.3 and 2.6l，respectively，P<0.01).ConclusionThe incidence and mortalityrates in males were significantly higher than in females and the over-all survival in rural area was significantly lower than in other areas of Pudong district，suggesting that surgical treatment could improve the prognosis of PLC. |
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